In vitro evaluation of antitrypanosomal activity and molecular docking of benzoylthioureas

• Published in: Parasitology international Vol. 80; p. 102225
• Main Authors: Pereira, Patricia M.L., Camargo, Priscila G., Fernandes, Bruna T., Flores-Junior, Luiz A.P., Dias, Luiza R.S., Lima, Camilo H.S., Pinge-Filho, Phileno, Lioni, Lucy M.Y., Yamada-Ogatta, Sueli F., Bispo, Marcelle L.F., Macedo Jr, Fernando
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2021
• Subjects: Chagas disease; Cruzain; CYP51; Molecular docking; Trypanosoma cruzi; Chagas disease; Cruzain; Molecular docking; CYP51; Trypanosoma cruzi

A series of sixteen benzoylthioureas derivatives were initially evaluated in vitro against the epimastigote form of Trypanosoma cruzi. All of the tested compounds inhibited the growth of this form of the parasite, and due to the promising anti-epimastigote activity from three of these compounds, the...