Development of Artefact-Free Imaging System for Accurate Meibomian Gland Reflectivity Assessment
To develop and evaluate a custom imaging system to provide high-resolution, wide depth-of-field, reflection-free, multispectral infrared (IR) imaging of the Meibomian glands. Lower eyelids of 15 volunteers were everted to obtain multispectral images of the Meibomian glands with custom imaging setup....
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Published in | Translational vision science & technology Vol. 12; no. 2; p. 9 |
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Main Authors | , , , , , |
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The Association for Research in Vision and Ophthalmology
01.02.2023
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Abstract | To develop and evaluate a custom imaging system to provide high-resolution, wide depth-of-field, reflection-free, multispectral infrared (IR) imaging of the Meibomian glands.
Lower eyelids of 15 volunteers were everted to obtain multispectral images of the Meibomian glands with custom imaging setup. Photographs were captured at 10 different ISO settings (from underexposure to overexposure) and using nine IR imaging filters (ranging from 600 nm to 1000 nm in 50-nm steps). Meibomian gland contrast (simple and Michelson) was calculated for the images to choose an optimal wavelength for Meibomian gland imaging and to determine differences in contrast across individuals.
The overall linear regression model showed a significant effect of wavelength on Meibomian gland contrast (Simple contrast: F = 7.24, P < 0.0001; Michelson contrast: F = 7.19, P < 0.0001). There was a significant negative correlation between Meibomian gland contrast and Meibomian gland depth for 750-nm IR filter (ρs= -0.579; P = 0.026).
Meibomian gland contrast varies across individuals and depends on Meibomian gland depth. IR filter of 750 nm is the optimal choice for Meibomian gland imaging because it provides images of greatest contrast.
This study adds to our understanding of Meibomian gland imaging. It has successfully demonstrated that Meibomian glands that are deeper in the tarsal plate require longer wavelengths for imaging. |
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AbstractList | To develop and evaluate a custom imaging system to provide high-resolution, wide depth-of-field, reflection-free, multispectral infrared (IR) imaging of the Meibomian glands.
Lower eyelids of 15 volunteers were everted to obtain multispectral images of the Meibomian glands with custom imaging setup. Photographs were captured at 10 different ISO settings (from underexposure to overexposure) and using nine IR imaging filters (ranging from 600 nm to 1000 nm in 50-nm steps). Meibomian gland contrast (simple and Michelson) was calculated for the images to choose an optimal wavelength for Meibomian gland imaging and to determine differences in contrast across individuals.
The overall linear regression model showed a significant effect of wavelength on Meibomian gland contrast (Simple contrast: F = 7.24, P < 0.0001; Michelson contrast: F = 7.19, P < 0.0001). There was a significant negative correlation between Meibomian gland contrast and Meibomian gland depth for 750-nm IR filter (ρs= -0.579; P = 0.026).
Meibomian gland contrast varies across individuals and depends on Meibomian gland depth. IR filter of 750 nm is the optimal choice for Meibomian gland imaging because it provides images of greatest contrast.
This study adds to our understanding of Meibomian gland imaging. It has successfully demonstrated that Meibomian glands that are deeper in the tarsal plate require longer wavelengths for imaging. PurposeTo develop and evaluate a custom imaging system to provide high-resolution, wide depth-of-field, reflection-free, multispectral infrared (IR) imaging of the Meibomian glands. MethodsLower eyelids of 15 volunteers were everted to obtain multispectral images of the Meibomian glands with custom imaging setup. Photographs were captured at 10 different ISO settings (from underexposure to overexposure) and using nine IR imaging filters (ranging from 600 nm to 1000 nm in 50-nm steps). Meibomian gland contrast (simple and Michelson) was calculated for the images to choose an optimal wavelength for Meibomian gland imaging and to determine differences in contrast across individuals. ResultsThe overall linear regression model showed a significant effect of wavelength on Meibomian gland contrast (Simple contrast: F = 7.24, P < 0.0001; Michelson contrast: F = 7.19, P < 0.0001). There was a significant negative correlation between Meibomian gland contrast and Meibomian gland depth for 750-nm IR filter (ρs= -0.579; P = 0.026). ConclusionsMeibomian gland contrast varies across individuals and depends on Meibomian gland depth. IR filter of 750 nm is the optimal choice for Meibomian gland imaging because it provides images of greatest contrast. Translational RelevanceThis study adds to our understanding of Meibomian gland imaging. It has successfully demonstrated that Meibomian glands that are deeper in the tarsal plate require longer wavelengths for imaging. |
Author | Maldonado-Codina, Carole Morgan, Philip B Swiderska, Kasandra Blackie, Caroline A Fergie, Martin Read, Michael L |
Author_xml | – sequence: 1 givenname: Kasandra surname: Swiderska fullname: Swiderska, Kasandra organization: Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK – sequence: 2 givenname: Caroline A surname: Blackie fullname: Blackie, Caroline A organization: Johnson & Johnson Vision, Inc., Jacksonville, FL, USA – sequence: 3 givenname: Carole surname: Maldonado-Codina fullname: Maldonado-Codina, Carole organization: Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK – sequence: 4 givenname: Martin surname: Fergie fullname: Fergie, Martin organization: Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK – sequence: 5 givenname: Philip B surname: Morgan fullname: Morgan, Philip B organization: Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK – sequence: 6 givenname: Michael L surname: Read fullname: Read, Michael L organization: Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK |
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Cites_doi | 10.1097/ICO.0000000000001818 10.1016/j.jtos.2018.07.001 10.1167/iovs.17-23631 10.1136/bmjophth-2020-000436 10.18637/jss.v082.i13 10.1038/s41598-021-87314-8 10.1038/sj.jid.5700418 10.1097/OPX.0000000000001636 10.1097/OPX.0000000000001767 10.1016/j.eclinm.2021.101132 10.1016/j.bspc.2019.101776 10.1038/sj.jid.5700289 10.1167/tvst.10.2.4 10.1097/ICO.0000000000000563 10.1145/1015706.1015720 10.1136/bjophthalmol-2021-318876 10.1097/OPX.0000000000001764 10.1007/s00417-020-05034-7 10.1167/tvst.8.6.37 10.3390/jcm9103181 10.1364/OSAC.1.001041 |
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Snippet | To develop and evaluate a custom imaging system to provide high-resolution, wide depth-of-field, reflection-free, multispectral infrared (IR) imaging of the... PurposeTo develop and evaluate a custom imaging system to provide high-resolution, wide depth-of-field, reflection-free, multispectral infrared (IR) imaging of... |
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SubjectTerms | Humans Lacrimal Apparatus, Eyelids, Orbit Meibomian Glands - diagnostic imaging |
Title | Development of Artefact-Free Imaging System for Accurate Meibomian Gland Reflectivity Assessment |
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