Astrocyte-derived CCL20 reinforces HIF-1-mediated hypoxic responses in glioblastoma by stimulating the CCR6-NF-κB signaling pathway

• Published in: Oncogene Vol. 37; no. 23; pp. 3070 - 3087
• Main Authors: Jin, Peng, Shin, Seung-Hyun, Chun, Yang-Sook, Shin, Hyun-Woo, Shin, Yong Jae, Lee, Yeri, Kim, Donggeon, Nam, Do-Hyun, Park, Jong-Wan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2018; Nature Publishing Group
• Subjects: 13/109; 13/21; 13/89; 13/95; 14/19; 38/79; 631/67/327; 631/80/86/820; 82/29; 82/51; 82/80; Animals; Apoptosis; Astrocytes; Astrocytes - metabolism; Astrocytes - pathology; Brain cancer; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Cancer; CCL20 protein; CCR6 protein; Cell Biology; Cell Hypoxia; Cell Line, Tumor; Chemokine CCL20 - genetics; Chemokine CCL20 - metabolism; Chemokine CXCL12 - genetics; Chemokine CXCL12 - metabolism; Chromatin; Glioblastoma; Glioblastoma - metabolism; Glioblastoma - pathology; Glioblastoma cells; Human Genetics; Humans; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factor 1a; Immunoblotting; Immunoprecipitation; Internal Medicine; Male; Medicine; Medicine & Public Health; Mice, Inbred BALB C; NF-kappa B - metabolism; NF-κB protein; Oncology; Phenotypes; Polymerase chain reaction; Receptors, CCR6 - metabolism; Signal Transduction; Stromal cells; Tumors; Vascularization; Xenograft Model Antitumor Assays; Xenografts

During tumor development, stromal cells are co-opted to the tumor milieu and provide favorable conditions for the tumor. Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). Given that cancer cells and astrocytes in glioblastomas...