The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37)

• Published in: Endocrinology (Philadelphia) Vol. 132; no. 1; p. 94
• Main Authors: Lu, M, Wheeler, M B, Leng, X H, Boyd, 3rd, A E
• Format: Journal Article
• Language: English
• Published: United States 01.01.1993
• Subjects: Animals; Calcium - metabolism; Cricetinae; Cyclic AMP - metabolism; Cytosol - metabolism; Egtazic Acid - pharmacology; Gastric Inhibitory Polypeptide - pharmacology; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin - metabolism; Insulin Secretion; Islets of Langerhans - drug effects; Islets of Langerhans - physiology; Nimodipine - pharmacology; Peptide Fragments; Peptides - pharmacology; Phosphatidylinositols - metabolism; Signal Transduction - physiology; Tumor Cells, Cultured

Using the glucose-responsive hamster beta-cell line (hamster insulin tumor cells), we examined the cellular mechanisms by which gastric inhibitory polypeptide (GIP) and glucagon-like peptide I(7-37) (GLP-I) potentiate glucose-stimulated insulin secretion. Glucose alone increased insulin secretion an...