Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules
The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins into primary urine.It is now accepted that the dysfunction of the sit diaphragm contributes to the development of proteinuria in several glo...
Saved in:
Published in | World journal of nephrology Vol. 3; no. 3; pp. 77 - 84 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
06.08.2014
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins into primary urine.It is now accepted that the dysfunction of the sit diaphragm contributes to the development of proteinuria in several glomerular diseases.Nephrin,a gene product of NPHS1,a gene for a congenital nephrotic syndrome of Finnish type,constitutes an extracellular domain of the slit diaphragm.Podocin was identified as a gene product of NPHS2,a gene for a familial steroid-resistant nephrotic syndrome of French.Podocin binds the cytoplasmic domain of nephrin.After then,CD2 associated protein,NEPH1 and transient receptor potential-6 were also found as crucial molecules of the slit diaphragm.In order to explore other novel molecules contributing to the development of proteinuria,we performed a subtraction hybridization assay with a normal rat glomerular RNA and a glomerular RNA of rats with a puromycin aminonucleoside nephropathy,a mimic of a human minimal change type nephrotic syndrome.Then we have found that synaptic vesicle protein 2B,ephrin-B1 and neurexin were already downregulated at the early stage of puromycin amino-nucleoside nephropathy,and that these molecules were localized close to nephrin.It is conceivable that these molecules are the slit diaphragm associated molecules,which participate in the regulation of the barrier function.These molecules could be targets to establish a novel therapy for nephrotic syndrome. |
---|---|
AbstractList | The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins into primary urine.It is now accepted that the dysfunction of the sit diaphragm contributes to the development of proteinuria in several glomerular diseases.Nephrin,a gene product of NPHS1,a gene for a congenital nephrotic syndrome of Finnish type,constitutes an extracellular domain of the slit diaphragm.Podocin was identified as a gene product of NPHS2,a gene for a familial steroid-resistant nephrotic syndrome of French.Podocin binds the cytoplasmic domain of nephrin.After then,CD2 associated protein,NEPH1 and transient receptor potential-6 were also found as crucial molecules of the slit diaphragm.In order to explore other novel molecules contributing to the development of proteinuria,we performed a subtraction hybridization assay with a normal rat glomerular RNA and a glomerular RNA of rats with a puromycin aminonucleoside nephropathy,a mimic of a human minimal change type nephrotic syndrome.Then we have found that synaptic vesicle protein 2B,ephrin-B1 and neurexin were already downregulated at the early stage of puromycin amino-nucleoside nephropathy,and that these molecules were localized close to nephrin.It is conceivable that these molecules are the slit diaphragm associated molecules,which participate in the regulation of the barrier function.These molecules could be targets to establish a novel therapy for nephrotic syndrome. The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins into primary urine. It is now accepted that the dysfunction of the sit diaphragm contributes to the development of proteinuria in several glomerular diseases. Nephrin, a gene product of NPHS1 , a gene for a congenital nephrotic syndrome of Finnish type, constitutes an extracellular domain of the slit diaphragm. Podocin was identified as a gene product of NPHS2 , a gene for a familial steroid-resistant nephrotic syndrome of French. Podocin binds the cytoplasmic domain of nephrin. After then, CD2 associated protein, NEPH1 and transient receptor potential-6 were also found as crucial molecules of the slit diaphragm. In order to explore other novel molecules contributing to the development of proteinuria, we performed a subtraction hybridization assay with a normal rat glomerular RNA and a glomerular RNA of rats with a puromycin aminonucleoside nephropathy, a mimic of a human minimal change type nephrotic syndrome. Then we have found that synaptic vesicle protein 2B, ephrin-B1 and neurexin were already downregulated at the early stage of puromycin aminonucleoside nephropathy, and that these molecules were localized close to nephrin. It is conceivable that these molecules are the slit diaphragm associated molecules, which participate in the regulation of the barrier function. These molecules could be targets to establish a novel therapy for nephrotic syndrome. The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins into primary urine. It is now accepted that the dysfunction of the sit diaphragm contributes to the development of proteinuria in several glomerular diseases. Nephrin, a gene product of NPHS1, a gene for a congenital nephrotic syndrome of Finnish type, constitutes an extracellular domain of the slit diaphragm. Podocin was identified as a gene product of NPHS2, a gene for a familial steroid-resistant nephrotic syndrome of French. Podocin binds the cytoplasmic domain of nephrin. After then, CD2 associated protein, NEPH1 and transient receptor potential-6 were also found as crucial molecules of the slit diaphragm. In order to explore other novel molecules contributing to the development of proteinuria, we performed a subtraction hybridization assay with a normal rat glomerular RNA and a glomerular RNA of rats with a puromycin aminonucleoside nephropathy, a mimic of a human minimal change type nephrotic syndrome. Then we have found that synaptic vesicle protein 2B, ephrin-B1 and neurexin were already downregulated at the early stage of puromycin aminonucleoside nephropathy, and that these molecules were localized close to nephrin. It is conceivable that these molecules are the slit diaphragm associated molecules, which participate in the regulation of the barrier function. These molecules could be targets to establish a novel therapy for nephrotic syndrome. |
Author | Yoshiyasu Fukusumi Naoko Miyauchi Taeko Hashimoto Akira Saito Hiroshi Kawachi |
AuthorAffiliation | Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan |
Author_xml | – sequence: 1 givenname: Yoshiyasu surname: Fukusumi fullname: Fukusumi, Yoshiyasu organization: Yoshiyasu Fukusumi, Naoko Miyauchi, Taeko Hashimoto, Akira Saito, Hiroshi Kawachi, Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan – sequence: 2 givenname: Naoko surname: Miyauchi fullname: Miyauchi, Naoko organization: Yoshiyasu Fukusumi, Naoko Miyauchi, Taeko Hashimoto, Akira Saito, Hiroshi Kawachi, Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan – sequence: 3 givenname: Taeko surname: Hashimoto fullname: Hashimoto, Taeko organization: Yoshiyasu Fukusumi, Naoko Miyauchi, Taeko Hashimoto, Akira Saito, Hiroshi Kawachi, Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan – sequence: 4 givenname: Akira surname: Saito fullname: Saito, Akira organization: Yoshiyasu Fukusumi, Naoko Miyauchi, Taeko Hashimoto, Akira Saito, Hiroshi Kawachi, Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan – sequence: 5 givenname: Hiroshi surname: Kawachi fullname: Kawachi, Hiroshi organization: Yoshiyasu Fukusumi, Naoko Miyauchi, Taeko Hashimoto, Akira Saito, Hiroshi Kawachi, Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25332898$$D View this record in MEDLINE/PubMed |
BookMark | eNpVkU1vFDEMhiNUREvpjTPKkQO75DsZDkio4qNSJS7lHGUTz2yqmWSbzGzVf09WXVblZMt-_Nry-xadpZwAofeUrKVk-vPjfVrv-Trytdav0AVjjKwUZeLsRX6Ormq9J4RQIhlh-g06Z5JzZjpzgfq7LRS3g2WOHs-uDDDjPhecYLct-VCsTymUPMEXfBMgzbGP3s0xJ5x7nPIeRlzHOOMQXZtww4RdrdlHN0PAUx7BLyPUd-h178YKV8d4if78-H53_Wt1-_vnzfW325XnvNMrSvogSU-U0sxz2WlDPGccAuUbKSkRWnYbIpUyLGhGwqYT4DUzolfUMGX4Jfr6rLtbNhME3w4ubrS7EidXnmx20f7fSXFrh7y3on1GdKIJfDwKlPywQJ3tFKuHcXQJ8lItVVQyRZTRDf30jPqSay3Qn9ZQYg_u2OaO3XMbudUH_MPL007wPy8awI9625yGh5iGE2N4R4wxXBJhRCeZMJK2zLTRv7X9nfE |
CitedBy_id | crossref_primary_10_18632_oncotarget_17165 crossref_primary_10_1007_s11427_015_4844_1 crossref_primary_10_1016_j_actatropica_2022_106311 crossref_primary_10_15591_mtp_2015_055 crossref_primary_10_2131_jts_45_681 crossref_primary_10_1007_s11906_015_0566_9 crossref_primary_10_3389_fped_2021_692727 crossref_primary_10_1002_cbf_3719 |
ContentType | Journal Article |
Copyright | 2014 Baishideng Publishing Group Inc. All rights reserved. 2014 |
Copyright_xml | – notice: 2014 Baishideng Publishing Group Inc. All rights reserved. 2014 |
DBID | 2RA 92L CQIGP ~WA NPM AAYXX CITATION 7X8 5PM |
DOI | 10.5527/wjn.v3.i3.77 |
DatabaseName | 维普_期刊 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库- 镜像站点 PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
DocumentTitleAlternate | Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules |
EISSN | 2220-6124 |
EndPage | 84 |
ExternalDocumentID | 10_5527_wjn_v3_i3_77 25332898 83908883504849524851484853 |
Genre | Journal Article Review |
GroupedDBID | 2RA 5VR 8WL 92L AFUIB ALMA_UNASSIGNED_HOLDINGS CCEZO CHBEP CIEJG CQIGP FA0 GX1 HYE RPM ~WA NPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c3397-10fd50f06672c359780c323ed13b55104759b056682d720db94ec7284f6182683 |
IEDL.DBID | RPM |
ISSN | 2220-6124 |
IngestDate | Fri Sep 01 02:33:32 EDT 2023 Fri Apr 12 08:46:31 EDT 2024 Fri Aug 23 00:34:14 EDT 2024 Tue Jul 04 17:19:38 EDT 2023 Wed Feb 14 10:02:38 EST 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | true |
Issue | 3 |
Keywords | Podocyte Synaptic vesicle protein 2B Ephrin-B1 Neurexin Slit diaphragm |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c3397-10fd50f06672c359780c323ed13b55104759b056682d720db94ec7284f6182683 |
Notes | Yoshiyasu Fukusumi;Naoko Miyauchi;Taeko Hashimoto;Akira Saito;Hiroshi Kawachi;Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Telephone: +81-25-2272160 Fax: +81-25-2270770 Author contributions: All authors contributed to this manuscript. Correspondence to: Hiroshi Kawachi, MD, PhD, Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-Dori, Niigata 951-8510, Japan. kawachi@med.niigata-u.ac.jp |
OpenAccessLink | https://doi.org/10.5527/wjn.v3.i3.77 |
PMID | 25332898 |
PQID | 1615260687 |
PQPubID | 23479 |
PageCount | 8 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4202494 proquest_miscellaneous_1615260687 crossref_primary_10_5527_wjn_v3_i3_77 pubmed_primary_25332898 chongqing_primary_83908883504849524851484853 |
PublicationCentury | 2000 |
PublicationDate | 20140806 |
PublicationDateYYYYMMDD | 2014-08-06 |
PublicationDate_xml | – month: 8 year: 2014 text: 20140806 day: 6 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | World journal of nephrology |
PublicationTitleAlternate | World Journal of Nephrology |
PublicationYear | 2014 |
Publisher | Baishideng Publishing Group Inc |
Publisher_xml | – name: Baishideng Publishing Group Inc |
References | 11733557 - J Clin Invest. 2001 Dec;108(11):1621-9 17667985 - Kidney Int. 2007 Oct;72(8):954-64 3397534 - J Immunol. 1988 Aug 1;141(3):807-14 15928710 - Nat Rev Mol Cell Biol. 2005 Jun;6(6):462-75 15331416 - Am J Pathol. 2004 Sep;165(3):923-36 10742096 - Nat Genet. 2000 Apr;24(4):349-54 16337696 - Trends Neurosci. 2006 Jan;29(1):21-9 10487848 - Am J Pathol. 1999 Sep;155(3):907-13 15882266 - Kidney Int. 2005 Jun;67(6):2239-53 21839714 - Am J Pathol. 2011 Oct;179(4):1719-32 16439426 - J Physiol. 2006 Apr 15;572(Pt 2):359-77 9741631 - Cell. 1998 Sep 4;94(5):667-77 15466855 - J Biol Chem. 2004 Dec 10;279(50):52124-31 10550324 - Am J Pathol. 1999 Nov;155(5):1681-7 21258036 - J Am Soc Nephrol. 2011 Mar;22(3):526-35 10624962 - Neuron. 1999 Dec;24(4):1003-16 16242404 - Neuron. 2005 Oct 20;48(2):229-36 12687700 - J Comp Neurol. 2003 May 19;460(1):106-22 12865409 - J Clin Invest. 2003 Jul;112(2):209-21 10587519 - J Clin Invest. 1999 Dec;104(11):1559-66 18715943 - Am J Physiol Renal Physiol. 2008 Nov;295(5):F1376-87 12764198 - Science. 2003 May 23;300(5623):1298-300 1621094 - Science. 1992 Jul 3;257(5066):50-6 8439414 - Neuron. 1993 Feb;10(2):307-15 8786425 - J Neurosci. 1996 Apr 15;16(8):2488-94 12506131 - Physiol Rev. 2003 Jan;83(1):253-307 5483882 - Lab Invest. 1970 Nov;23(5):489-96 11750881 - Cytokine Growth Factor Rev. 2002 Feb;13(1):75-85 17116414 - Semin Cell Dev Biol. 2006 Dec;17(6):667-74 12386277 - Nephrol Dial Transplant. 2002;17 Suppl 9:20-2 21184239 - Pediatr Nephrol. 2011 Oct;26(10):1775-80 11416156 - Mol Cell Biol. 2001 Jul;21(14):4829-36 1496002 - Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7075-9 10393930 - Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7962-7 12937130 - Am J Pathol. 2003 Sep;163(3):889-99 9648885 - J Neurochem. 1998 Jul;71(1):356-65 21048075 - Am J Physiol Regul Integr Comp Physiol. 2011 Feb;300(2):R340-8 12444221 - J Am Soc Nephrol. 2002 Dec;13(12):3005-15 16303855 - Am J Physiol Renal Physiol. 2006 May;290(5):F1241-52 15469835 - Dev Cell. 2004 Oct;7(4):465-80 1590354 - Am J Physiol. 1992 May;262(5 Pt 1):C1119-24 8163501 - J Biol Chem. 1994 Apr 22;269(16):11987-92 16943307 - J Am Soc Nephrol. 2006 Oct;17(10):2748-59 2452168 - J Cell Biol. 1988 Apr;106(4):1141-9 23989654 - JAMA. 2013 Aug 21;310(7):706-14 22398409 - Kidney Int. 2012 Jun;81(12 ):1212-25 15879175 - Science. 2005 Jun 17;308(5729):1801-4 12424224 - FASEB J. 2003 Jan;17(1):115-7 16111551 - Brain Res Brain Res Rev. 2005 Sep;49(2):211-26 20685822 - Am J Physiol Renal Physiol. 2010 Oct;299(4):F689-701 12094214 - Nat Rev Mol Cell Biol. 2002 Jul;3(7):475-86 9751164 - J Neurochem. 1998 Oct;71(4):1339-47 10514378 - Science. 1999 Oct 8;286(5438):312-5 10792613 - Kidney Int. 2000 May;57(5):1949-61 11337370 - Am J Pathol. 2001 May;158(5):1723-31 14633131 - Kidney Int. 2003 Dec;64(6):2092-9 11912254 - J Am Soc Nephrol. 2002 Apr;13(4):946-56 2202736 - J Cell Biol. 1990 Sep;111(3):1255-63 8132583 - J Biol Chem. 1994 Mar 18;269(11):8576-81 9267020 - Cell. 1997 Aug 8;90(3):403-4 15924139 - Nat Genet. 2005 Jul;37(7):739-44 10504499 - Kidney Int. 1999 Oct;56(4):1481-91 9660941 - Mol Cell. 1998 Mar;1(4):575-82 12506137 - J Am Soc Nephrol. 2003 Jan;14(1):46-56 10344367 - Nephrol Dial Transplant. 1999 May;14(5):1234-7 12480962 - Nephrol Dial Transplant. 2003 Jan;18(1):70-6 11786407 - Am J Pathol. 2002 Jan;160(1):131-9 19266252 - Clin Exp Nephrol. 2009 Aug;13(4):275-80 8910372 - J Biol Chem. 1996 Nov 1;271(44):27770-5 |
References_xml | |
SSID | ssj0001052027 |
Score | 1.9355701 |
SecondaryResourceType | review_article |
Snippet | The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins... |
SourceID | pubmedcentral proquest crossref pubmed chongqing |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 77 |
SubjectTerms | Minireviews |
Title | Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules |
URI | http://lib.cqvip.com/qk/61591X/201403/83908883504849524851484853.html https://www.ncbi.nlm.nih.gov/pubmed/25332898 https://search.proquest.com/docview/1615260687 https://pubmed.ncbi.nlm.nih.gov/PMC4202494 |
Volume | 3 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NS8MwHA3OkxdR_JpfRNCb7bokbTpvMhwiTDwo7FbaNNXJlk4357_vS790evNSaJuWkvcjv_dLX14IOdcpkq6WXSdVqXCE8qQTB1mIU6GYp5QsDUyH98Htk7gb-aM14tdrYQrRvkrGrplMXTN-KbSVs6nq1DqxzsOwL5g1uhOdFmlJzn-U6MXEilV2MFmK3K2_WOfz1bhL7o65K-2eewwMB2VGaN0UXnLz_IYcsZqV_lDN34rJHylosEU2K-5Ir8tv3CZr2uyQ7PF7BRUtdd0URJQaDZhye7E2Jbii5arcrJqmo3lGTb7UEwquuaAIFDwRP09pXEGmUzotd8_V813yNLh57N861eYJjuLgGBhes9T3MqthZYr71mhIccZ12uUJWJJnff4SsJ8gZKlkXpr0hFYSySoLbMkR8j2ybnKjDwgVgEzGva7dLRe5TCQqAS-LVeCzIMl6uk0um46MZqVJRgTihQEM_A5DBIow65yGygtH3iYXdV83rVGKWKgiQBUteTTmkZRtclYDESHm7Y-M2Oj8Yx5Zloo6LAjRZr8EpnlTjW6byBXImgbWT3v1DsKs8NWuwurw308ekQ3wKVHoA4Njsr54_9An4CyL5LSI0S_kbO1b |
link.rule.ids | 230,315,733,786,790,891,27955,27956,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB2VcoALH-Jr-TQS3Eg2aztxlhuqqBboVhy2qLcodpx2oesUurtI_Hqe42TplhNcIiV2okQz9rxxnt8QvbIVgq5Vo6gylYykSVRUZnWOU2l4YowKAqbTw2xyJD8ep8c7lPZ7YVrSvtHz2J0tYjc_bbmV5wsz7Hliw8_TPcm90J0cXqPrGK88vZSkt0srntvBVaC5e4Wx4c-vLl6LeC5i5avucWAcJBq511M4bdzJd0SJ7bj0F9i8ypm8FIT2b9OX_vUD9-RbvFrq2Py6ouz4z993h251sJS9C813ace6e1TP_mzOYoEyzoBxmbPwgMZf7PUO3rKw4bfuVgBZUzPXrO0ZA4xdMvgg7ihPFqzsvMFWbBEK89qL-3S0_362N4m6ugyREYAvmLnrKk1qT4_lRqRew8gILmw1EhoALPESghrAKst5pXhS6bG0RiEO1pnPZnLxgHZd4-wjYhLeoMrxyBfiRZiU2mhAvtJkKc90PbYDerOxUHEe9DcKYDrMjYCOmH2Q33lRNiR1OIoBve6NuOmNLMf7QAEfKNaimItCqQG97C1cYDj5fySls83qovAAGClelqPPw2DxzZN6txmQ2vKFTQcv1b3dAgu3kt2dRR__950v6MZkNj0oDj4cfnpCNwHbZEtDzJ7S7vLHyj4DNFrq5-1A-A3BzA9Z |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VVkJcoIjX8ihGght5rO2Ns72htqvyaNVDK1VcrPjVLnSdhe4uEr--4zhZdsutl0hJ7EjWjD3fOJ-_AXhvDQZdK_qJ0YYnXOciqQpX4i3XNNdaRAHTo-Pi8Ix_OR-cr5T6akj7Wo1TfzVJ_fiy4VZOJzrreGLZydEep0HojmdT47J7sIVzloqVRL3ZXgn8Dioi1T2ojGV_fvh0wdIxS0WovEcR52CyUQZNhcvaX_zCSLEem_4DnLd5kyuBaPQIvndDiPyTn-l8plL995a6453GuA0PW3hKPsUmj2HD-ifgTv8d0iKROk4Q6xJv0RPq8LDTPdgl8eCva3cCSe2Irxf2iiCcnRH0RexRXUxI1XqFNWQSC_Ta66dwNjo43TtM2voMiWYIY3AFd2aQu0CTpZoNgpaRZpRZ02cKgVgepAQVAqyipEbQ3Kght1pgPHRFyGpK9gw2fe3tCyAcvUJUw34oyIvhkiutEPpVuhjQQrmh7cHHpZXkNOpwSMR2uEYihMRVCPO8IM6GyR1eWQ8-dIZctsZsJ_iBRD-QCybHTArRg3edlSVOq_CvpPK2nl_LAIQx1StKbPM8Wn35pc51eiDW_GHZIEh2r79BKzfS3a1VX96551u4f7I_kt8-H399BQ8QvfGGjVi8hs3Z77l9gwhppnaauXADQ2IR2Q |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Therapeutic+target+for+nephrotic+syndrome%3A+Identification+of+novel+slit+diaphragm+associated+molecules&rft.jtitle=World+journal+of+nephrology&rft.au=Fukusumi%2C+Yoshiyasu&rft.date=2014-08-06&rft.issn=2220-6124&rft.eissn=2220-6124&rft.volume=3&rft.issue=3&rft.spage=77&rft_id=info:doi/10.5527%2Fwjn.v3.i3.77&rft.externalDBID=n%2Fa&rft.externalDocID=10_5527_wjn_v3_i3_77 |
thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F61591X%2F61591X.jpg |