Synthetic phospholipids with high purity fatty acids

Phospholipids derived from fatty acids are increasingly used by the pharmaceutical industry as excipients and also as active pharmaceutical ingredients (API) themselves. Newly developed HPLC‐CAD (charged aerosol detection) methods allow the resolution of phospholipids with the same headgroup but dif...

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Published inLipid technology Vol. 26; no. 9; pp. 202 - 205
Format Journal Article
LanguageGerman
English
Published Weinheim WILEY-VCH Verlag 01.09.2014
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Fatty acids
Pharmaceutical industry
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Abstract Phospholipids derived from fatty acids are increasingly used by the pharmaceutical industry as excipients and also as active pharmaceutical ingredients (API) themselves. Newly developed HPLC‐CAD (charged aerosol detection) methods allow the resolution of phospholipids with the same headgroup but different fatty acid chains. A new manufacturing process has been established on multi‐Kg scale, which enables the manufacture of phospholipids meeting the quality requirements for use as excipients or APIs. Such products can now be obtained in significantly higher chemical purities than previously possible, with no unqualified impurity exceeding the International Conference on Harmonisation (ICH) limit of 0.15%.
AbstractList Phospholipids derived from fatty acids are increasingly used by the pharmaceutical industry as excipients and also as active pharmaceutical ingredients (API) themselves. Newly developed HPLC‐CAD (charged aerosol detection) methods allow the resolution of phospholipids with the same headgroup but different fatty acid chains. A new manufacturing process has been established on multi‐Kg scale, which enables the manufacture of phospholipids meeting the quality requirements for use as excipients or APIs. Such products can now be obtained in significantly higher chemical purities than previously possible, with no unqualified impurity exceeding the International Conference on Harmonisation (ICH) limit of 0.15%.
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10.2174/092986712803251584
10.1007/s13361-012-0410-2
10.1007/s11095-010-0130-x
10.1517/17425247.2011.614228
10.1016/j.cocis.2013.06.001
10.1016/j.ijpharm.2013.03.054
10.3109/08982104.2014.905957
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SubjectTerms Fatty acids
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Title Synthetic phospholipids with high purity fatty acids
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