Stability-Indicating LC Method for the Determination of Prasugrel Hydrochloride in Pharmaceutical Dosage Form

• Published in: Scientia pharmaceutica Vol. 80; no. 2; pp. 379 - 391
• Main Authors: Ahirrao, Vinod K, Patil, Chabutai S, Bembalkar, Saroj B, Ubale, Sanjay B, Marathe, Rajendra P, Nawale, Rajesh B, Landge, Mahadev G, Pawar, Rajendra P
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2012; Österreichische Apotheker-Verlagsgesellschaft
• Subjects: Pharmaceutical preparation; Prasugrel hydrochloride; Liquid chromatography; Method validation

A simple, rapid and precise method was developed for the quantitative estimation of prasugrel hydrochloride in pharmaceutical dosage form. A chromatographic separation of prasugrel and its degradants was achieved with Zorbax XDB C(8), 150 × 4.6 mm, 3.5μm analytical column using aqueous solution of 0...