Automatic bone marrow segmentation for precise [177Lu]Lu‐PSMA‐617 dosimetry

• Published in: Medical physics (Lancaster) Vol. 52; no. 6; pp. 3970 - 3980
• Main Authors: Lu, Zhonglin, Hu, Jiaxi, Chen, Gefei, Jiang, Han, Shih, Cheng‐Ting, Afshar‐Oromieh, Ali, Rominger, Axel, Shi, Kuangyu, Mok, Greta S. P.
• Format: Journal Article
• Language: English
• Published: United States 01.06.2025
• Subjects: [177Lu]Lu‐PSMA‐617; Automation; bone marrow; Bone Marrow - diagnostic imaging; Bone Marrow - radiation effects; Dipeptides - therapeutic use; dosimetry; Heterocyclic Compounds, 1-Ring - therapeutic use; Humans; Image Processing, Computer-Assisted - methods; Lutetium - therapeutic use; Male; Radioisotopes; Radiometry; segmentation; Single Photon Emission Computed Tomography Computed Tomography; SPECT/CT; segmentation; dosimetry; [177Lu]Lu‐PSMA‐617; SPECT/CT; bone marrow

Background Bone marrow (BM) is the dominant dose‐limiting organ in [177Lu]Lu‐PSMA‐617 therapy for patients with metastasized castration resistant prostate cancer, where BM dosimetry is challenging due to segmentation. Purpose We aim to develop an automatic image‐based segmentation method on peri‐the...