Distinctive Effects of Three Intravenous Anesthetics on the Inward Rectifier (IK1) and the Delayed Rectifier (IK) Potassium Currents in Myocardium: Implications for the Mechanism of Action

The mechanism(s) of action of anesthetics on cell membrane ionic currents are not known. To investigate this further the effects of clinically relevant concentrations of ketamine, methohexital, and propofol on the delayed rectifier (IK) and the inward rectifier (IK1) currents of single dispersed gui...

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Bibliographic Details
Published inAnesthesia and analgesia Vol. 76; no. 1; pp. 18 - 23
Main Author Baum, Victor C.
Format Journal Article
LanguageEnglish
Published Hagerstown, MD International Anesthesia Research Society 01.01.1993
Lippincott
Subjects
Action Potentials - drug effects
Anesthetics. Neuromuscular blocking agents
Animals
Biological and medical sciences
Electrophysiology
Guinea Pigs
Heart - drug effects
Heart - physiology
Ketamine - pharmacology
Medical sciences
Methohexital - pharmacology
Neuropharmacology
Pharmacology. Drug treatments
Potassium Channels - drug effects
Propofol - pharmacology
Heart
Cell culture
Intravenous administration
Rodentia
Electrophysiology
Ionic current
In vitro
Vertebrata
Mammalia
Guinea pig
General anesthetic
Animal
Plasma membrane
Mechanism of action
Potassium
Comparative study
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Summary:The mechanism(s) of action of anesthetics on cell membrane ionic currents are not known. To investigate this further the effects of clinically relevant concentrations of ketamine, methohexital, and propofol on the delayed rectifier (IK) and the inward rectifier (IK1) currents of single dispersed guinea pig ventricular myocytes were studied. These voltage-gated currents are major components of cardiac cell electrophysiologic function regulating resting potential and repolarization. Each of the three anesthetics had a distinct spectrum of activity. Ketamine (10M) decreased IK1 (P < 0.05) but had no effect on IK. Methohexital (10M) had no significant effect on either current. Propofol (2.8 × 10M) resulted in significant depression of IK (P < 0.001) but had no effect on IK1. These results suggest that these intravenous anesthetics may have more specific effects on sarcolemma than volatile anesthetics, whose effects may be more generalized membrane effects.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0003-2999
1526-7598
DOI:10.1213/00000539-199301000-00004