Accumulation of phosphorylated α-synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration
The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated α‐synuclein in oligodendrocytes. However, it is uncertain whether phosphorylated α‐synuclein accumulates in astrocytes of MSA patients. We immunohistochemically examined the frontal and temporal lobes, basal...
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| Published in | Neuropathology Vol. 36; no. 2; pp. 157 - 167 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Australia
Blackwell Publishing Ltd
01.04.2016
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| ISSN | 0919-6544 1440-1789 1440-1789 |
| DOI | 10.1111/neup.12243 |
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| Abstract | The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated α‐synuclein in oligodendrocytes. However, it is uncertain whether phosphorylated α‐synuclein accumulates in astrocytes of MSA patients. We immunohistochemically examined the frontal and temporal lobes, basal ganglia, cerebellum, brainstem and spinal cord of patients with MSA (n = 15) and Lewy body disease (n = 20), and also in control subjects (n = 20). Accumulation of abnormally phosphorylated and aggregated α‐synuclein was found in subpial and periventricular astrocytes in six of the 15 patients with MSA (40%). The structures were confined to the subpial surface of the ventro‐lateral part of the spinal cord and brainstem, as well as the subependymal region of the lateral ventricles. They were not visualized by Gallyas‐Braak staining, and were immunonegative for ubiquitin and p62. Immunoelectron microscopy revealed that the phosphorylated α‐synuclein‐immunoreactive structures in astrocytes were non‐fibrillar and associated with granular and vesicular structures. The extent of phosphorylated α‐synuclein‐immunoreactive astrocytes was correlated with disease duration. No such structures were found in Lewy body disease or controls. Accumulation of phosphorylated α‐synuclein can occur in subpial and periventricular astrocytes in patients with MSA, especially in those with a long disease duration. |
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| AbstractList | The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated α-synuclein in oligodendrocytes. However, it is uncertain whether phosphorylated α-synuclein accumulates in astrocytes of MSA patients. We immunohistochemically examined the frontal and temporal lobes, basal ganglia, cerebellum, brainstem and spinal cord of patients with MSA (n = 15) and Lewy body disease (n = 20), and also in control subjects (n = 20). Accumulation of abnormally phosphorylated and aggregated α-synuclein was found in subpial and periventricular astrocytes in six of the 15 patients with MSA (40%). The structures were confined to the subpial surface of the ventro-lateral part of the spinal cord and brainstem, as well as the subependymal region of the lateral ventricles. They were not visualized by Gallyas-Braak staining, and were immunonegative for ubiquitin and p62. Immunoelectron microscopy revealed that the phosphorylated α-synuclein-immunoreactive structures in astrocytes were non-fibrillar and associated with granular and vesicular structures. The extent of phosphorylated α-synuclein-immunoreactive astrocytes was correlated with disease duration. No such structures were found in Lewy body disease or controls. Accumulation of phosphorylated α-synuclein can occur in subpial and periventricular astrocytes in patients with MSA, especially in those with a long disease duration. The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated alpha -synuclein in oligodendrocytes. However, it is uncertain whether phosphorylated alpha -synuclein accumulates in astrocytes of MSA patients. We immunohistochemically examined the frontal and temporal lobes, basal ganglia, cerebellum, brainstem and spinal cord of patients with MSA (n=15) and Lewy body disease (n=20), and also in control subjects (n=20). Accumulation of abnormally phosphorylated and aggregated alpha -synuclein was found in subpial and periventricular astrocytes in six of the 15 patients with MSA (40%). The structures were confined to the subpial surface of the ventro-lateral part of the spinal cord and brainstem, as well as the subependymal region of the lateral ventricles. They were not visualized by Gallyas-Braak staining, and were immunonegative for ubiquitin and p62. Immunoelectron microscopy revealed that the phosphorylated alpha -synuclein-immunoreactive structures in astrocytes were non-fibrillar and associated with granular and vesicular structures. The extent of phosphorylated alpha -synuclein-immunoreactive astrocytes was correlated with disease duration. No such structures were found in Lewy body disease or controls. Accumulation of phosphorylated alpha -synuclein can occur in subpial and periventricular astrocytes in patients with MSA, especially in those with a long disease duration. The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated α-synuclein in oligodendrocytes. However, it is uncertain whether phosphorylated α-synuclein accumulates in astrocytes of MSA patients. We immunohistochemically examined the frontal and temporal lobes, basal ganglia, cerebellum, brainstem and spinal cord of patients with MSA (n = 15) and Lewy body disease (n = 20), and also in control subjects (n = 20). Accumulation of abnormally phosphorylated and aggregated α-synuclein was found in subpial and periventricular astrocytes in six of the 15 patients with MSA (40%). The structures were confined to the subpial surface of the ventro-lateral part of the spinal cord and brainstem, as well as the subependymal region of the lateral ventricles. They were not visualized by Gallyas-Braak staining, and were immunonegative for ubiquitin and p62. Immunoelectron microscopy revealed that the phosphorylated α-synuclein-immunoreactive structures in astrocytes were non-fibrillar and associated with granular and vesicular structures. The extent of phosphorylated α-synuclein-immunoreactive astrocytes was correlated with disease duration. No such structures were found in Lewy body disease or controls. Accumulation of phosphorylated α-synuclein can occur in subpial and periventricular astrocytes in patients with MSA, especially in those with a long disease duration.The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated α-synuclein in oligodendrocytes. However, it is uncertain whether phosphorylated α-synuclein accumulates in astrocytes of MSA patients. We immunohistochemically examined the frontal and temporal lobes, basal ganglia, cerebellum, brainstem and spinal cord of patients with MSA (n = 15) and Lewy body disease (n = 20), and also in control subjects (n = 20). Accumulation of abnormally phosphorylated and aggregated α-synuclein was found in subpial and periventricular astrocytes in six of the 15 patients with MSA (40%). The structures were confined to the subpial surface of the ventro-lateral part of the spinal cord and brainstem, as well as the subependymal region of the lateral ventricles. They were not visualized by Gallyas-Braak staining, and were immunonegative for ubiquitin and p62. Immunoelectron microscopy revealed that the phosphorylated α-synuclein-immunoreactive structures in astrocytes were non-fibrillar and associated with granular and vesicular structures. The extent of phosphorylated α-synuclein-immunoreactive astrocytes was correlated with disease duration. No such structures were found in Lewy body disease or controls. Accumulation of phosphorylated α-synuclein can occur in subpial and periventricular astrocytes in patients with MSA, especially in those with a long disease duration. The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated α‐synuclein in oligodendrocytes. However, it is uncertain whether phosphorylated α‐synuclein accumulates in astrocytes of MSA patients. We immunohistochemically examined the frontal and temporal lobes, basal ganglia, cerebellum, brainstem and spinal cord of patients with MSA ( n = 15) and Lewy body disease ( n = 20), and also in control subjects ( n = 20). Accumulation of abnormally phosphorylated and aggregated α‐synuclein was found in subpial and periventricular astrocytes in six of the 15 patients with MSA (40%). The structures were confined to the subpial surface of the ventro‐lateral part of the spinal cord and brainstem, as well as the subependymal region of the lateral ventricles. They were not visualized by Gallyas‐Braak staining, and were immunonegative for ubiquitin and p62. Immunoelectron microscopy revealed that the phosphorylated α‐synuclein‐immunoreactive structures in astrocytes were non‐fibrillar and associated with granular and vesicular structures. The extent of phosphorylated α‐synuclein‐immunoreactive astrocytes was correlated with disease duration. No such structures were found in Lewy body disease or controls. Accumulation of phosphorylated α‐synuclein can occur in subpial and periventricular astrocytes in patients with MSA, especially in those with a long disease duration. |
| Author | Wakabayashi, Koichi Kakita, Akiyoshi Kon, Tomoya Tomiyama, Masahiko Toyoshima, Yasuko Tanji, Kunikazu Kurotaki, Hidekachi Takahashi, Hitoshi Miki, Yasuo Yamada, Masahito Mori, Fumiaki Nakamura, Keiko |
| Author_xml | – sequence: 1 givenname: Keiko surname: Nakamura fullname: Nakamura, Keiko organization: Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki – sequence: 2 givenname: Fumiaki surname: Mori fullname: Mori, Fumiaki email: neuropal@hirosaki-u.ac.jp organization: Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki – sequence: 3 givenname: Tomoya surname: Kon fullname: Kon, Tomoya organization: Departments of Neurology, Aomori – sequence: 4 givenname: Kunikazu surname: Tanji fullname: Tanji, Kunikazu organization: Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki – sequence: 5 givenname: Yasuo surname: Miki fullname: Miki, Yasuo organization: Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki – sequence: 6 givenname: Masahiko surname: Tomiyama fullname: Tomiyama, Masahiko organization: Departments of Neurology, Aomori – sequence: 7 givenname: Hidekachi surname: Kurotaki fullname: Kurotaki, Hidekachi organization: Pathology, Aomori Prefectural Central Hospital, Aomori – sequence: 8 givenname: Yasuko surname: Toyoshima fullname: Toyoshima, Yasuko organization: Departments of Pathology, Niigata, Japan – sequence: 9 givenname: Akiyoshi surname: Kakita fullname: Kakita, Akiyoshi organization: Pathological Neuroscience, Brain Research Institute, University of Niigata, Niigata, Japan – sequence: 10 givenname: Hitoshi surname: Takahashi fullname: Takahashi, Hitoshi organization: Departments of Pathology, Niigata, Japan – sequence: 11 givenname: Masahito surname: Yamada fullname: Yamada, Masahito organization: Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa – sequence: 12 givenname: Koichi surname: Wakabayashi fullname: Wakabayashi, Koichi organization: Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26331967$$D View this record in MEDLINE/PubMed |
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| Keywords | multiple system atrophy ultrastructure astrocyte α-synuclein subpial surface |
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Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies. Neurobiol Dis 2004; 17: 155-162. 2001; 101 1994; 117 1990; 79 2015; 3 2012; 124 1995; 90 2005; 110 2002; 176 1993; 60 2004; 25 1988; 76 1992; 107 2002; 4 2010; 120 2005; 65 2010; 285 2001; 27 2014; 29 2004; 107 2007; 33 1996; 16 2008; 71 1998; 44 1998; 152 2005; 25 1996; 55 1999; 9 1997; 388 2007; 114 1989; 94 2000; 19 2003; 105 2013; 33 1990; 49 2004; 17 2000; 99 2015; 65 2003; 9 1982; 7 1998; 249 2006; 325 2001; 12 2012; 4 1999; 259 2010; 30 1992; 83 2012; 119 1992; 84 e_1_2_6_51_1 e_1_2_6_53_1 e_1_2_6_32_1 e_1_2_6_30_1 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_36_1 e_1_2_6_11_1 Piao YS (e_1_2_6_20_1) 2003; 105 e_1_2_6_34_1 e_1_2_6_17_1 e_1_2_6_15_1 e_1_2_6_38_1 Baba M (e_1_2_6_12_1) 1998; 152 e_1_2_6_43_1 e_1_2_6_41_1 Piao YS (e_1_2_6_16_1) 2000; 19 e_1_2_6_9_1 e_1_2_6_5_1 e_1_2_6_7_1 e_1_2_6_24_1 e_1_2_6_49_1 e_1_2_6_3_1 e_1_2_6_22_1 e_1_2_6_28_1 e_1_2_6_45_1 e_1_2_6_47_1 e_1_2_6_52_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_50_1 e_1_2_6_14_1 e_1_2_6_35_1 Piao YS (e_1_2_6_26_1) 2001; 101 e_1_2_6_33_1 e_1_2_6_39_1 e_1_2_6_37_1 e_1_2_6_42_1 e_1_2_6_21_1 e_1_2_6_40_1 Terada S (e_1_2_6_18_1) 2003; 105 e_1_2_6_8_1 e_1_2_6_4_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_48_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_29_1 e_1_2_6_44_1 e_1_2_6_27_1 e_1_2_6_46_1 |
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| Snippet | The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated α‐synuclein in oligodendrocytes. However, it is uncertain whether... The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated α-synuclein in oligodendrocytes. However, it is uncertain whether... The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated alpha -synuclein in oligodendrocytes. However, it is uncertain... |
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| SubjectTerms | Aged alpha-Synuclein - metabolism astrocyte Astrocytes - metabolism Astrocytes - pathology Brain - metabolism Brain - pathology Female Humans Immunohistochemistry Inclusion Bodies - pathology Lewy Body Disease - pathology Male Microscopy, Immunoelectron Middle Aged multiple system atrophy Multiple System Atrophy - metabolism Multiple System Atrophy - pathology Phosphorylation Spinal Cord - metabolism Spinal Cord - pathology subpial surface Time Factors ultrastructure α-synuclein |
| Title | Accumulation of phosphorylated α-synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration |
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