Prevalence of pulmonary hypertension in sickle cell anaemia patients of a tertiary hospital in Nigeria
Sickle cell disease (SCD) is an inherited haemoglobinopathy characterised by recurrent organ hypoxia-reperfusion cycles which may result in repeated organ damage including the lungs and heart. In SCD, pulmonary hypertension is a known complication that may precede or complicate acute chest syndrome...
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Published in | Nigerian medical journal Vol. 55; no. 2; pp. 161 - 165 |
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Format | Journal Article |
Language | English |
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Medknow Publications and Media Pvt. Ltd
01.03.2014
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Abstract | Sickle cell disease (SCD) is an inherited haemoglobinopathy characterised by recurrent organ hypoxia-reperfusion cycles which may result in repeated organ damage including the lungs and heart. In SCD, pulmonary hypertension is a known complication that may precede or complicate acute chest syndrome which is often fatal. This study seeks to know the prevalence of pulmonary hypertension and its relationship with clinical and laboratory parameters in sickle cell disease patients attending a tertiary hospital in Lagos.
This was a case - control study involving patients with sickle cell disease recruited from adult sickle cell clinic of Lagos State University Teaching Hospital, Ikeja and HbAA controls matched for age and sex from a tertiary educational institution in Lagos. Both the patients and controls were subjected to echocardiography and pulmonary hypertension was deduced from their cardiac tricuspid regurgitant jet velocity. Other parameters measured were age, body mass index, full blood count, red cell indices, foetal haemoglobin, chest X-ray, liver function tests, lactate dehydrogenase and pulmonary function tests. Consenting patients were 56 HbSS in steady state and 28 HbAA controls matched for age and sex. Data was analysed using SPSS version 16.0.
The mean age of patients was 22 ± 6 years. In two 2 of 56 (3.6%) of the participants with sickle cell disease, the pulmonary artery pressure was > 25mmHg and there was significant difference in the mean of the pulmonary artery pressure of the control and that of the patients (P-value 0.013). Also, using the appropriate correlation tests, there was significant relationship between the pulmonary artery pressure and lactate dehydrogenase, aspartate transferase and haematocrit in patients with sickle cell disease.
Sickle cell disease is an independent cause of pulmonary artery hypertension. Variation in cardiovascular reactions to recurrent hyperhaemolysis and hyperdynamic state in sickle cell disease may explain differences in the development of cardiac complications. Exploration of these reactions may reveal other therapeutic measures to prevent complications in sickle cell disease. Clinical assessment of adult patients with sickle cell disease should include echocardiography. |
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AbstractList | BACKGROUNDSickle cell disease (SCD) is an inherited haemoglobinopathy characterised by recurrent organ hypoxia-reperfusion cycles which may result in repeated organ damage including the lungs and heart. In SCD, pulmonary hypertension is a known complication that may precede or complicate acute chest syndrome which is often fatal. This study seeks to know the prevalence of pulmonary hypertension and its relationship with clinical and laboratory parameters in sickle cell disease patients attending a tertiary hospital in Lagos.MATERIALS AND METHODSThis was a case - control study involving patients with sickle cell disease recruited from adult sickle cell clinic of Lagos State University Teaching Hospital, Ikeja and HbAA controls matched for age and sex from a tertiary educational institution in Lagos. Both the patients and controls were subjected to echocardiography and pulmonary hypertension was deduced from their cardiac tricuspid regurgitant jet velocity. Other parameters measured were age, body mass index, full blood count, red cell indices, foetal haemoglobin, chest X-ray, liver function tests, lactate dehydrogenase and pulmonary function tests. Consenting patients were 56 HbSS in steady state and 28 HbAA controls matched for age and sex. Data was analysed using SPSS version 16.0.RESULTSThe mean age of patients was 22 ± 6 years. In two 2 of 56 (3.6%) of the participants with sickle cell disease, the pulmonary artery pressure was > 25mmHg and there was significant difference in the mean of the pulmonary artery pressure of the control and that of the patients (P-value 0.013). Also, using the appropriate correlation tests, there was significant relationship between the pulmonary artery pressure and lactate dehydrogenase, aspartate transferase and haematocrit in patients with sickle cell disease.CONCLUSIONSickle cell disease is an independent cause of pulmonary artery hypertension. Variation in cardiovascular reactions to recurrent hyperhaemolysis and hyperdynamic state in sickle cell disease may explain differences in the development of cardiac complications. Exploration of these reactions may reveal other therapeutic measures to prevent complications in sickle cell disease. Clinical assessment of adult patients with sickle cell disease should include echocardiography. Sickle cell disease (SCD) is an inherited haemoglobinopathy characterised by recurrent organ hypoxia-reperfusion cycles which may result in repeated organ damage including the lungs and heart. In SCD, pulmonary hypertension is a known complication that may precede or complicate acute chest syndrome which is often fatal. This study seeks to know the prevalence of pulmonary hypertension and its relationship with clinical and laboratory parameters in sickle cell disease patients attending a tertiary hospital in Lagos. This was a case - control study involving patients with sickle cell disease recruited from adult sickle cell clinic of Lagos State University Teaching Hospital, Ikeja and HbAA controls matched for age and sex from a tertiary educational institution in Lagos. Both the patients and controls were subjected to echocardiography and pulmonary hypertension was deduced from their cardiac tricuspid regurgitant jet velocity. Other parameters measured were age, body mass index, full blood count, red cell indices, foetal haemoglobin, chest X-ray, liver function tests, lactate dehydrogenase and pulmonary function tests. Consenting patients were 56 HbSS in steady state and 28 HbAA controls matched for age and sex. Data was analysed using SPSS version 16.0. The mean age of patients was 22 ± 6 years. In two 2 of 56 (3.6%) of the participants with sickle cell disease, the pulmonary artery pressure was > 25mmHg and there was significant difference in the mean of the pulmonary artery pressure of the control and that of the patients (P-value 0.013). Also, using the appropriate correlation tests, there was significant relationship between the pulmonary artery pressure and lactate dehydrogenase, aspartate transferase and haematocrit in patients with sickle cell disease. Sickle cell disease is an independent cause of pulmonary artery hypertension. Variation in cardiovascular reactions to recurrent hyperhaemolysis and hyperdynamic state in sickle cell disease may explain differences in the development of cardiac complications. Exploration of these reactions may reveal other therapeutic measures to prevent complications in sickle cell disease. Clinical assessment of adult patients with sickle cell disease should include echocardiography. |
Audience | Academic |
Author | Onadeko, Babatunde O Sagoe, Aba O Dosunmu, Adedoyin O Akinola, Rachael A Akinbami, Akinsegun A Balogun, Taiwo M Onakoya, Josephine A Adeyeye, Olufunke O Daniel, Folashade A |
AuthorAffiliation | 1 Department of Medicine, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria 3 Department of Chemical Pathology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria 2 Department of Radiology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria Department of Haematology and Blood Transfusion, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria |
AuthorAffiliation_xml | – name: 2 Department of Radiology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – name: Department of Haematology and Blood Transfusion, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – name: 1 Department of Medicine, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – name: 3 Department of Chemical Pathology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria |
Author_xml | – sequence: 1 givenname: Adedoyin O surname: Dosunmu fullname: Dosunmu, Adedoyin O organization: Department of Haematology and Blood Transfusion, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – sequence: 2 givenname: Taiwo M surname: Balogun fullname: Balogun, Taiwo M organization: Department of Haematology and Blood Transfusion, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – sequence: 3 givenname: Olufunke O surname: Adeyeye fullname: Adeyeye, Olufunke O organization: Department of Medicine, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – sequence: 4 givenname: Folashade A surname: Daniel fullname: Daniel, Folashade A organization: Department of Medicine, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – sequence: 5 givenname: Rachael A surname: Akinola fullname: Akinola, Rachael A organization: Department of Radiology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – sequence: 6 givenname: Josephine A surname: Onakoya fullname: Onakoya, Josephine A organization: Department of Chemical Pathology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – sequence: 7 givenname: Akinsegun A surname: Akinbami fullname: Akinbami, Akinsegun A organization: Department of Haematology and Blood Transfusion, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – sequence: 8 givenname: Aba O surname: Sagoe fullname: Sagoe, Aba O organization: Department of Haematology and Blood Transfusion, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria – sequence: 9 givenname: Babatunde O surname: Onadeko fullname: Onadeko, Babatunde O organization: Department of Medicine, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria |
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Snippet | Sickle cell disease (SCD) is an inherited haemoglobinopathy characterised by recurrent organ hypoxia-reperfusion cycles which may result in repeated organ... BACKGROUNDSickle cell disease (SCD) is an inherited haemoglobinopathy characterised by recurrent organ hypoxia-reperfusion cycles which may result in repeated... |
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SubjectTerms | Causes of Complications and side effects Distribution Original Pulmonary hypertension Sickle cell anemia |
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Title | Prevalence of pulmonary hypertension in sickle cell anaemia patients of a tertiary hospital in Nigeria |
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