Modulation of the Default Mode Network in First-Episode, Drug-Naïve Major Depressive Disorder via Acupuncture at Baihui (GV20) Acupoint
Previous neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain disorder. However, few studies have been performed to investigate whether or not acupuncture might modulate the DMN in patients with major depressive di...
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| Published in | Frontiers in human neuroscience Vol. 10; p. 230 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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17.05.2016
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| Abstract | Previous neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain disorder. However, few studies have been performed to investigate whether or not acupuncture might modulate the DMN in patients with major depressive disorder (MDD). Thereby, the aim of the present study was to assess alterations of the DMN induced by acupuncture stimulation in patients with first-episode, drug-naïve MDD.
Twenty nine patients with first-episode, drug-naïve MDD and 29 healthy subjects were enrolled in this study. All the healthy subjects underwent 6-min resting-state functional magnetic resonance imaging (R-fMRI) scan. While patients underwent acupuncture stimulation for 20-min electro-acupuncture stimulation (EAS) at Baihui acupoint (GV20) and two 6-min R-fMRI scans before and after EAS. Based on the precuneus/posterior cingulate cortex (PC/PCC) as the seed region, functional connectivity (FC) method was adopted to examine abnormal DMN in patients by comparing with healthy subjects and to evaluate the influence of EAS on intrinsic connectivity within the DMN in patients with MDD.
Compared to healthy subjects, MDD patients had abnormal DMN. Moreover, results showed that EAS at GV20 induced increased FC between the PC/PCC and bilateral anterior cingulate cortex (ACC), and decreased FC between the PC/PCC and left middle prefrontal cortex, left angualr gyrus and bilateral hippocampus/parahippocampus (HIPP/paraHIPP) in patients with MDD, which were the main brain regions showing significant differences between the patients and healthy subjects.
Our findings provide imaging evidence to support that GV20-related acupuncture stimulation may modulate the DMN in patients with first-episode, drug-naïve MDD. This study may partly interpret the neural mechanisms of acupuncture at GV20 which is used to treat patients with MDD in clinical. |
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| AbstractList | Background
: Previous neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain disorder. However, few studies have been performed to investigate whether or not acupuncture might modulate the DMN in patients with major depressive disorder (MDD). Thereby, the aim of the present study was to assess alterations of the DMN induced by acupuncture stimulation in patients with first-episode, drug-naïve MDD.
Materials and Methods
: Twenty nine patients with first-episode, drug-naïve MDD and 29 healthy subjects were enrolled in this study. All the healthy subjects underwent 6-min resting-state functional magnetic resonance imaging (R-fMRI) scan. While patients underwent acupuncture stimulation for 20-min electro-acupuncture stimulation (EAS) at Baihui acupoint (GV20) and two 6-min R-fMRI scans before and after EAS. Based on the precuneus/posterior cingulate cortex (PC/PCC) as the seed region, functional connectivity (FC) method was adopted to examine abnormal DMN in patients by comparing with healthy subjects and to evaluate the influence of EAS on intrinsic connectivity within the DMN in patients with MDD.
Results
: Compared to healthy subjects, MDD patients had abnormal DMN. Moreover, results showed that EAS at GV20 induced increased FC between the PC/PCC and bilateral anterior cingulate cortex (ACC), and decreased FC between the PC/PCC and left middle prefrontal cortex, left angualr gyrus and bilateral hippocampus/parahippocampus (HIPP/paraHIPP) in patients with MDD, which were the main brain regions showing significant differences between the patients and healthy subjects.
Conclusion
: Our findings provide imaging evidence to support that GV20-related acupuncture stimulation may modulate the DMN in patients with first-episode, drug-naïve MDD. This study may partly interpret the neural mechanisms of acupuncture at GV20 which is used to treat patients with MDD in clinical. Previous neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain disorder. However, few studies have been performed to investigate whether or not acupuncture might modulate the DMN in patients with major depressive disorder (MDD). Thereby, the aim of the present study was to assess alterations of the DMN induced by acupuncture stimulation in patients with first-episode, drug-naïve MDD. Twenty nine patients with first-episode, drug-naïve MDD and 29 healthy subjects were enrolled in this study. All the healthy subjects underwent 6-min resting-state functional magnetic resonance imaging (R-fMRI) scan. While patients underwent acupuncture stimulation for 20-min electro-acupuncture stimulation (EAS) at Baihui acupoint (GV20) and two 6-min R-fMRI scans before and after EAS. Based on the precuneus/posterior cingulate cortex (PC/PCC) as the seed region, functional connectivity (FC) method was adopted to examine abnormal DMN in patients by comparing with healthy subjects and to evaluate the influence of EAS on intrinsic connectivity within the DMN in patients with MDD. Compared to healthy subjects, MDD patients had abnormal DMN. Moreover, results showed that EAS at GV20 induced increased FC between the PC/PCC and bilateral anterior cingulate cortex (ACC), and decreased FC between the PC/PCC and left middle prefrontal cortex, left angualr gyrus and bilateral hippocampus/parahippocampus (HIPP/paraHIPP) in patients with MDD, which were the main brain regions showing significant differences between the patients and healthy subjects. Our findings provide imaging evidence to support that GV20-related acupuncture stimulation may modulate the DMN in patients with first-episode, drug-naïve MDD. This study may partly interpret the neural mechanisms of acupuncture at GV20 which is used to treat patients with MDD in clinical. BACKGROUNDPrevious neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain disorder. However, few studies have been performed to investigate whether or not acupuncture might modulate the DMN in patients with major depressive disorder (MDD). Thereby, the aim of the present study was to assess alterations of the DMN induced by acupuncture stimulation in patients with first-episode, drug-naïve MDD. MATERIALS AND METHODSTwenty nine patients with first-episode, drug-naïve MDD and 29 healthy subjects were enrolled in this study. All the healthy subjects underwent 6-min resting-state functional magnetic resonance imaging (R-fMRI) scan. While patients underwent acupuncture stimulation for 20-min electro-acupuncture stimulation (EAS) at Baihui acupoint (GV20) and two 6-min R-fMRI scans before and after EAS. Based on the precuneus/posterior cingulate cortex (PC/PCC) as the seed region, functional connectivity (FC) method was adopted to examine abnormal DMN in patients by comparing with healthy subjects and to evaluate the influence of EAS on intrinsic connectivity within the DMN in patients with MDD. RESULTSCompared to healthy subjects, MDD patients had abnormal DMN. Moreover, results showed that EAS at GV20 induced increased FC between the PC/PCC and bilateral anterior cingulate cortex (ACC), and decreased FC between the PC/PCC and left middle prefrontal cortex, left angualr gyrus and bilateral hippocampus/parahippocampus (HIPP/paraHIPP) in patients with MDD, which were the main brain regions showing significant differences between the patients and healthy subjects. CONCLUSIONOur findings provide imaging evidence to support that GV20-related acupuncture stimulation may modulate the DMN in patients with first-episode, drug-naïve MDD. This study may partly interpret the neural mechanisms of acupuncture at GV20 which is used to treat patients with MDD in clinical. Background: Previous neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain disorder. However, few studies have been performed to investigate whether or not acupuncture might modulate the DMN in patients with major depressive disorder (MDD). Thereby, the aim of the present study was to assess alterations of the DMN induced by acupuncture stimulation in patients with first-episode, drug-naïve MDD. Materials and Methods: 29 patients with first-episode, drug-naïve MDD and 29 healthy subjects were enrolled in this study. All the healthy subjects underwent 6-minute resting-state functional magnetic resonance imaging (R-fMRI) scan. While patients underwent acupuncture stimulation for 20-minute electro-acupuncture stimulation (EAS) at Baihui acupoint (GV20) and two 6-minute R-fMRI scans before and after EAS. Based on the precuneus/posterior cingulate cortex (PC/PCC) as the seed region, functional connectivity (FC) method was adopted to examine abnormal DMN in patients by comparing with healthy subjects and to evaluate the influence of EAS on intrinsic connectivity within the DMN in patients with MDD. Results: Compared to healthy subjects, MDD patients had abnormal DMN. Moreover, results showed that EAS at GV20 induced increased FC between the PC/PCC and bilateral anterior cingulate cortex(ACC), and decreased FC between the PC/PCC and left middle prefrontal cortex, left angualr gyrus and bilateral hippocampus/parahippocampus (HIPP/paraHIPP) in patients with MDD, which were the main brain regions showing significant differences between the patients and healthy subjects. Conclusions: Our findings provide imaging evidence to support that GV20-related acupuncture stimulation may modulate the DMN in patients with first-episode, drug-naïve MDD. This study may partly interpret the neural mechanisms of acupuncture at GV20 which is used to treat patients with MDD in clinical. |
| Author | Liu, Yanfei Tang, Lijun Liu, Huimei Duan, Gaoxiong He, Qianchao Deng, Demao Pang, Yong Tao, Jien Liao, Hai |
| AuthorAffiliation | 1 Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China 4 Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China 2 Life Science Research Center, School of Life Science and Technology, Xidian University Xi’an, China 3 Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China |
| AuthorAffiliation_xml | – name: 1 Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China – name: 4 Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China – name: 2 Life Science Research Center, School of Life Science and Technology, Xidian University Xi’an, China – name: 3 Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China |
| Author_xml | – sequence: 1 givenname: Demao surname: Deng fullname: Deng, Demao organization: Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China – sequence: 2 givenname: Hai surname: Liao fullname: Liao, Hai organization: Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China – sequence: 3 givenname: Gaoxiong surname: Duan fullname: Duan, Gaoxiong organization: Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China – sequence: 4 givenname: Yanfei surname: Liu fullname: Liu, Yanfei organization: Life Science Research Center, School of Life Science and Technology, Xidian University Xi'an, China – sequence: 5 givenname: Qianchao surname: He fullname: He, Qianchao organization: Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China – sequence: 6 givenname: Huimei surname: Liu fullname: Liu, Huimei organization: Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China – sequence: 7 givenname: Lijun surname: Tang fullname: Tang, Lijun organization: Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China – sequence: 8 givenname: Yong surname: Pang fullname: Pang, Yong organization: Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China – sequence: 9 givenname: Jien surname: Tao fullname: Tao, Jien organization: Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine Nanning, China |
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| Keywords | acupuncture fMRI Baihui functional connectivity major depressive disorder |
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| Snippet | Previous neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain disorder.... Background: Previous neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain... BACKGROUNDPrevious neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain... Background : Previous neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with... |
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| SubjectTerms | Acupuncture Brain mapping Brain research Chinese medicine Cortex (cingulate) Cortex (parietal) Functional magnetic resonance imaging Head injuries Hospitals Medical imaging Mental depression Mental disorders Neural networks Neuroimaging Neuroscience NMR Nuclear magnetic resonance Parahippocampal gyrus Prefrontal cortex Studies |
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| Title | Modulation of the Default Mode Network in First-Episode, Drug-Naïve Major Depressive Disorder via Acupuncture at Baihui (GV20) Acupoint |
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