Adaptive two-stage optimal designs for phase II clinical studies that allow early futility stopping

• Published in: Sequential analysis Vol. 38; no. 2; pp. 199 - 213
• Main Authors: Shan, Guogen, Zhang, Hua, Jiang, Tao
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 03.04.2019; Taylor & Francis Ltd
• Subjects: Adaptive design; branch-and-bound algorithm; Clinical trials; Computation; Design optimization; Medical research; optimal design; sample size; Search algorithms; Simon's optimal design

Adaptive designs play an important role in contemporary clinical trials to make designs flexible and efficient. In cancer clinical trials, given a relatively small sample size, it is important to obtain as much information as possible during this phase. We propose a new adaptive optimal design that...