Adult Patients with Hbs-Only Phenotype of Sickle Cell Disease have a Decreased Arginine/Asymmetric Dimethylarginine Ratio

• Published in: Medical principles and practice pp. 1 - 14
• Main Authors: Onwasigwe, Chiemelie Raluchukwu, Ugwu, Angela Ogechukwu, Madu, Anazoeze Jude, Anigbogu, Ikechukwu Okwudili, Egolum, Chidiebele Michael
• Format: Journal Article
• Language: English
• Published: Switzerland S. Karger AG 23.04.2025
• Subjects: Asymmetric dimethylarginine; Leg ulcers; Arginine; Sickle cell disease; Arginine/asymmetric dimethylarginine ratio

Objective: Leg ulcer is the most common cutaneous manifestation of sickle cell disease (SCD). Asymmetric dimethylarginine (ADMA) inhibits nitric oxide synthase, reducing nitric oxide availability and causing endothelial dysfunction. This study examined the relationship between arginine/ADMA ratio an...