Discovery of anticancer targets for triple-negative breast cancer through comparative analysis of gene dependency score

• Published in: Biotechnology and bioprocess engineering Vol. 29; no. 6; pp. 1061 - 1070
• Main Authors: Kim, Bo Kyung, Kim, Gahee, Hur, Wonhee, Choi, Yoojin, Hwangbo, Suhyun, Ryu, Jae Yong
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.12.2024; Springer Nature B.V; 한국생물공학회
• Subjects: Biomarkers; Biotechnology; Breast cancer; breast neoplasms; Cell survival; Cell viability; Chemistry; Chemistry and Materials Science; Comparative analysis; drugs; ErbB-2 protein; Genes; ILK protein; Industrial and Production Engineering; Medical prognosis; neoplasm cells; prognosis; Research Paper; RhoA protein; Survival analysis; Therapeutic targets; therapeutics; Tumor cell lines; 생물공학; Biomarker; Gene dependency score; Target discovery; Triple-negative breast cancer

Patients with triple-negative breast cancer (TNBC) often face an unfavorable prognosis due to the lack of targeted therapy. Thus, identifying drug targets specific to the TNBC subtype is crucial for effective treatment. Here, we propose a strategy to identify potential inhibitory targets specific to...