Dan’e fukang decoction reduces hemorrhage in a rat model of mifepristone induced incomplete abortion and may correlate with cell adhesion molecule signaling interference

• Published in: Journal of ethnopharmacology Vol. 337; no. Pt 3; p. 118984
• Main Authors: Ni, Qi-cheng, Zhong, Rui-hua, Yang, Ye, Li, Guo-ting, Yang, Wen-jie, Zhou, Jie-yun, Hu, Ying-yi, Wu, Jianhui, Zhu, Yan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 30.01.2025
• Subjects: Abortifacient Agents, Steroidal - pharmacology; Abortion, Induced; Angelica sinensis; animal models; Animals; axons; blood serum; blood stasis; Bupleurum; carcinoma; cell adhesion; Cell adhesion molecules (CAMs); coagulation; Corydalis yanhusuo; Curcuma zedoaria; Cyperus rotundus; Dan’e fukang decoction (DFD); Disease Models, Animal; drugs; Drugs, Chinese Herbal - pharmacology; endometriosis; eosin; estrogens; Female; focal adhesions; genes; Glycyrrhiza uralensis; Hemorrhage; Incomplete abortion; intercellular adhesion molecule-1; lipids; mechanism of action; Mifepristone - pharmacology; Oriental traditional medicine; Paeonia lactiflora; Panax notoginseng; pharmacology; Pregnancy; progesterone; protein synthesis; Rats; Rats, Sprague-Dawley; Salvia; sequence analysis; Signal Transduction - drug effects; solvents; Sparganium eurycarpum; transcriptomics; Western blotting; Incomplete abortion; Dan’e fukang decoction (DFD); Hemorrhage; Cell adhesion molecules (CAMs)

Dan’e fukang decoction (DFD) is a traditional Chinese medicine formula. DFD obtains 10 herbs, including Salvia yunnanensis C.H.Wright (Zidanshen), Curcuma zedoaria (Christm.) Roscoe (Ezhu), Angelica sinensis (Oliv.) Diels (Danggui), Cyperus rotundus L. (Xiangfuzi), Corydalis yanhusuo (Y.H.Chou &...