The BTBR T+tf/J mouse model for autism spectrum disorders–in search of biomarkers

• Published in: Behavioural brain research Vol. 251; pp. 25 - 34
• Main Authors: Meyza, Ksenia Z., Defensor, Erwin B., Jensen, Ashley L., Corley, Michael J., Pearson, Brandon L., Pobbe, Roger L.H., Bolivar, Valerie J., Blanchard, D. Caroline, Blanchard, Robert J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2013
• Subjects: Agenesis of corpus callosum; Animal Communication; Animals; Autism spectrum disorder; Behavior, Animal - physiology; Biomarkers; BTBR T+tf/J mouse; Child; Child Development Disorders, Pervasive - genetics; Child Development Disorders, Pervasive - physiopathology; Disease Models, Animal; Humans; Mice; Mice, Inbred Strains; Phenotype; Social Behavior; Social interaction; Biomarkers; Social interaction; Agenesis of corpus callosum; Autism spectrum disorder; BTBR T+tf/J mouse; BTBR T(+)tf/J mouse

► The BTBR T+tf/J mouse is an animal model of autism spectrum disorders with strong face validity. ► The neuroanatomy and physiology of the BTBR mouse resembles that of some individuals with ASD. ► Lack of corpus callosum and impaired synaptogenesis and neurogenesis may be linked with heparan sulfat...