A hyperspectral fluorescence lifetime probe for skin cancer diagnosis

• Published in: Review of scientific instruments Vol. 78; no. 12; p. 123101
• Main Authors: De Beule, P A A, Dunsby, C, Galletly, N P, Stamp, G W, Chu, A C, Anand, U, Anand, P, Benham, C D, Naylor, A, French, P M W
• Format: Journal Article
• Language: English
• Published: United States 01.12.2007
• Subjects: Biomarkers, Tumor - analysis; Equipment Design; Equipment Failure Analysis; Humans; Luminescent Measurements - instrumentation; Molecular Probe Techniques; Reproducibility of Results; Sensitivity and Specificity; Skin Neoplasms - diagnosis; Spectrometry, Fluorescence - instrumentation; Spectrometry, Fluorescence - methods

The autofluorescence of biological tissue can be exploited for the detection and diagnosis of disease but, to date, its complex nature and relatively weak signal levels have impeded its widespread application in biology and medicine. We present here a portable instrument designed for the in situ sim...