Mechanistic insights into allosteric regulation of the reductase component of p -hydroxyphenylacetate 3-hydroxylase by p -hydroxyphenylacetate: a model for effector-controlled activity of redox enzymes

• Published in: RSC chemical biology Vol. 6; no. 1; pp. 81 - 93
• Main Authors: Visitsatthawong, Surawit, Anuwan, Piyanuch, Lawan, Narin, Chaiyen, Pimchai, Wongnate, Thanyaporn
• Format: Journal Article
• Language: English
• Published: England RSC 02.01.2025
• Subjects: Chemistry

Understanding how an enzyme regulates its function through substrate or allosteric regulation is crucial for controlling metabolic pathways. Some flavin-dependent monooxygenases (FDMOs) have evolved an allosteric mechanism to produce reduced flavin while minimizing the use of NADH and the production...