Effect of 4-phenylbutyrate addition timing on titer of Fc-fusion protein in Chinese hamster ovary cell cultures

• Published in: Biotechnology and bioprocess engineering Vol. 29; no. 4; pp. 712 - 720
• Main Authors: Lim, Jungae, Lim, Jin-Hyuk, Lee, Ji-Hoon, Cheon, Su-Hwan, Lee, Guewha, Kim, Z-Hun, Kim, Dong-Il
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.08.2024; Springer Nature B.V; 한국생물공학회
• Subjects: Acids; Antibodies; Apoptosis; Bioengineering; Biotechnology; Biotechnology industry; Cell culture; Cell cycle; Cell death; Cell fusion; Chemistry; Chemistry and Materials Science; Cricetulus griseus; Development strategies; Engineering; Fc receptors; Fusion protein; growth retardation; Industrial and Production Engineering; industry; Ovaries; Phenylbutyric acid; Product quality; Productivity; Protein folding; protein synthesis; Proteins; recombinant proteins; Research Paper; therapeutics; 생물공학; 4-phenylbutyric acid; Mammalian cell culture; Chinese hamster ovary cell cultures; Recombinant proteins

Chinese hamster ovary (CHO) cells have been widely used in the biotechnology industry for the production of therapeutic proteins, leading to various research efforts to increase the productivity of therapeutic proteins. Although the addition of small molecule enhancers in CHO cell culture can enhanc...