Cell line-specific impact of dexamethasone on the bioprocessing of Chinese hamster ovary cells

• Published in: Biotechnology and bioprocess engineering Vol. 29; no. 4; pp. 699 - 711
• Main Authors: An, Yeong Bin, Kang, Da Eun, Yoo, Jiseon, You, Weon-Kyoo, Baik, Jong Youn, Hong, Jong Kwang
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.08.2024; Springer Nature B.V; 한국생물공학회
• Subjects: Antibodies; Apoptosis; Bioprocessing; Biotechnology; Cell culture; cell growth; Cell lines; Cell viability; Chemistry; Chemistry and Materials Science; Cricetulus griseus; Culture media; Dexamethasone; Glucocorticoids; glucose; growth retardation; Industrial and Production Engineering; longevity; Metabolites; Ovaries; Research Paper; 생물공학; Media optimization; Bioprocessing; Dexamethasone; CHO cell line; Glucocorticoid receptor

This study explored the cell line-specific effects of dexamethasone (DEX) on three antibody-producing Chinese hamster ovary (CHO) clones derived from different parental host cell lines: CHO-K1, -S, and -DG44. The CHO-K1 and -DG44 cell lines displayed DEX-concentration-dependent growth inhibition but...