Evaluation of transarterial chemoembolization combined with percutaneous ethanol ablation for large hepatocellular carcinoma

AIM： To assess the effects of combined transcatheter arterial chemoembolization （TACE） and percutaneous ethanol ablation （PEA） in patients with large hepatocellular carcinoma （HCC）. METHODS： A total of 63 patients with unresectable large HCC were treated with TACE followed by PEA. The largest dimens...

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Published inWorld journal of gastroenterology : WJG Vol. 17; no. 26; pp. 3145 - 3150
Main Authors Gao, Fei, Gu, Yang-Kui, Fan, Wei-Jun, Zhang, Liang, Huang, Jin-Hua
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Co., Limited 14.07.2011
Subjects
Brief
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Chemoembolization, Therapeutic - methods
Combined Modality Therapy - methods
Ethanol - administration & dosage
Ethanol - therapeutic use
Female
Humans
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Male
Middle Aged
Proportional Hazards Models
Survival Rate
乙醇
化学
手术切除
无水酒精
栓塞
结合治疗
肝癌
评价
Hepatocellular carcinoma
Combination therapy
Ethanol ablation
Chemoembolization
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Summary:AIM： To assess the effects of combined transcatheter arterial chemoembolization （TACE） and percutaneous ethanol ablation （PEA） in patients with large hepatocellular carcinoma （HCC）. METHODS： A total of 63 patients with unresectable large HCC were treated with TACE followed by PEA. The largest dimension of the tumors ranged from 5.3 cm to 17.8 cm. The survival rates, acute effects, toxicity and prognostic factors were analyzed. RESULTS： The cumulative survival rates at 1, 3 and 5 years were 59.4%, 28.4% and 15.8%, respectively （a median survival of 27.7 too）. Tumor area was reduced by more than 50% in 30 （47.6%） cases. In 56 cases with increased α-fetoprotein （AFP） values, AFP level was declined by more than 75%. The combined thera- py was generally well tolerated. Only two patients died from variceal bleeding associated with the therapy. The Cox proportional hazards model showed that the num- ber of tumors, the tumor margin and the ethanol dose were independent prognostic factors. CONCLUSION： The combined TACE and PEA therapy is a promising approach for unresectable large HCC.
Bibliography:14-1219/R
Hepatocellular carcinoma; Chemoembolizaion; Ethanol ablation; Combination therapy
AIM： To assess the effects of combined transcatheter arterial chemoembolization （TACE） and percutaneous ethanol ablation （PEA） in patients with large hepatocellular carcinoma （HCC）. METHODS： A total of 63 patients with unresectable large HCC were treated with TACE followed by PEA. The largest dimension of the tumors ranged from 5.3 cm to 17.8 cm. The survival rates, acute effects, toxicity and prognostic factors were analyzed. RESULTS： The cumulative survival rates at 1, 3 and 5 years were 59.4%, 28.4% and 15.8%, respectively （a median survival of 27.7 too）. Tumor area was reduced by more than 50% in 30 （47.6%） cases. In 56 cases with increased α-fetoprotein （AFP） values, AFP level was declined by more than 75%. The combined thera- py was generally well tolerated. Only two patients died from variceal bleeding associated with the therapy. The Cox proportional hazards model showed that the num- ber of tumors, the tumor margin and the ethanol dose were independent prognostic factors. CONCLUSION： The combined TACE and PEA therapy is a promising approach for unresectable large HCC.
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Telephone: +86-20-87343272 Fax: +86-20-87343272
Correspondence to: Dr. Jin-Hua Huang, Department of Medical Imaging and Interventional Radiology, Cancer Center, Sun Yat-Sen University, 651 East Dongfeng Road, Guangzhou 510060, Guangdong Province, China. hjinh@mail.sysu.edu.cn
Author contributions: Gao F and Gu YK performed the majority of study; Fan WJ provided financial support and collected cases; Zhang L provided analytical tools and edited the manuscript; Huang JH designed the study and wrote the manuscript.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v17.i26.3145