Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 326; no. 5; pp. L618 - L626
• Main Authors: Pathinayake, Prabuddha S, Hsu, Alan C-Y, Nichol, Kristy S, Horvat, Jay C, Hansbro, Philip M, Wark, Peter A B
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.05.2024
• Series: Targeting Airway Immunity in Lung Disease
• Subjects: Activator protein 1; Asthma; Asthma - genetics; Asthma - metabolism; Asthma - pathology; Basal cells; Biopsy; Bronchi - metabolism; Bronchi - pathology; CCAAT/enhancer-binding protein; Cell differentiation; Cells, Cultured; Cytokines - metabolism; eIF-2 Kinase - genetics; eIF-2 Kinase - metabolism; Endoplasmic reticulum; Endoplasmic Reticulum Stress; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - pathology; Epithelium; Female; Gene expression; Humans; Immune response; Leukocytes (neutrophilic); Lymphocytes T; Pathogenesis; Protein folding; Proteins; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Respiratory tract; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction; siRNA; Stress; Thymic Stromal Lymphopoietin; Thymus; TLR3 protein; Toll-Like Receptor 3 - genetics; Toll-Like Receptor 3 - metabolism; Toll-like receptors; Transcription Factor CHOP - genetics; Transcription Factor CHOP - metabolism; Transcription factors; Unfolded Protein Response; ER stress; unfolded protein response; severe neutrophilic asthma; TSLP

Thymic stromal lymphopoietin (TSLP) is an epithelial-derived pleiotropic cytokine that regulates T-helper 2 (Th2) immune responses in the lung and plays a major role in severe uncontrolled asthma. Emerging evidence suggests a role for endoplasmic reticulum (ER) stress in the pathogenesis of asthma....