Chromatographic and Computational Assessment of Potential Biological Activity of N-(Substituted Phenyl)- 2-Chloroacetamides Applying Multivariate Methods

• Published in: Journal of liquid chromatography & related technologies Vol. 38; no. 18; pp. 1691 - 1698
• Main Authors: Apostolov, Suzana, Vastag, Gyöngyi, Matijević, Borko, Petrović, Slobodan
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis 08.11.2015; Taylor & Francis Ltd
• Subjects: Biological activity; chloroacetamides; chromatographic retention constant; Chromatography; lipophilicity; multivariate methods; Pharmacokinetics; pharmakocinetic predictors; Principal components analysis; Regression analysis; RP-TLC; Thin layer chromatography

The lipophilicity of the newly synthesized N-(substituted phenyl)-2-chloroacetamides, as the most commonly used molecular descriptor of a potential biological activity was the subject of research. The lipophilicity of the tested derivatives was determined by applying the reversed-phase thin-layer ch...