Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease

• Published in: Science translational medicine Vol. 8; no. 338; p. 338ra66
• Main Authors: Brier, Matthew R, Gordon, Brian, Friedrichsen, Karl, McCarthy, John, Stern, Ari, Christensen, Jon, Owen, Christopher, Aldea, Patricia, Su, Yi, Hassenstab, Jason, Cairns, Nigel J, Holtzman, David M, Fagan, Anne M, Morris, John C, Benzinger, Tammie L S, Ances, Beau M
• Format: Journal Article
• Language: English
• Published: United States 11.05.2016
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - physiopathology; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - metabolism; Brain - diagnostic imaging; Brain - metabolism; Cognition - physiology; Female; Humans; Male; Peptide Fragments - cerebrospinal fluid; Peptide Fragments - metabolism; Positron-Emission Tomography; tau Proteins - cerebrospinal fluid; tau Proteins - metabolism

Alzheimer's disease (AD) is characterized by two molecular pathologies: cerebral β-amyloidosis in the form of β-amyloid (Aβ) plaques and tauopathy in the form of neurofibrillary tangles, neuritic plaques, and neuropil threads. Until recently, only Aβ could be studied in humans using positron em...