Exploring the antimicrobial potential of chitosan nanoparticles: synthesis, characterization and impact on Pseudomonas aeruginosa virulence factors
The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of on the rise. Addressing this challenge necessitates exploring strategies that would complement existing antimicrobial agents, by substances mitigating b...
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| Published in | Nanoscale advances Vol. 6; no. 12; pp. 3093 - 3105 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
RSC
11.06.2024
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| Subjects | |
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| Abstract | The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of
on the rise. Addressing this challenge necessitates exploring strategies that would complement existing antimicrobial agents,
by substances mitigating bacterial virulence without eliciting selective pressure for resistance emergence. In this respect, free-form chitosan has demonstrated promising efficacy, prompting our investigation into reinforcing its effects through nanoparticle formulations. Our study focuses on the preparation of chitosan nanoparticles under suitable conditions while emphasizing the challenges associated with stability that can affect biological activity. These challenges are mitigated by introducing quaternized chitosan, which ensures colloidal stability in the culture media. Our approach led to the production of trimethylchitosan nanoparticles with a median size of 103 nm, circularity of 0.967, and a charge of 14.9 ± 3.1 mV, stable within a one-month period in a water stock solution, showing promising attributes for further valorization. Furthermore, the study delves into the antimicrobial activity of trimethylchitosan nanoparticles on
and confirms the benefits of both nanoformulation and modification of chitosan, as our prepared nanoparticles inhibit 50% of the bacterial population at concentration ≥160 mg L
within tested strains. Additionally, we identified a concentration of 5 mg L
that no longer impedes bacterial growth, allowing reliable verification of the effect of the prepared nanoparticles on
virulence factors, including motility, protease activity, hemolytic activity, rhamnolipids, pyocyanin, and biofilm production. Although trimethylchitosan nanoparticles exhibit promise as an effective antibiofilm agent (reducing biofilm development by 50% at concentrations ranging from 80 to 160 mg L
) their impact on virulence manifestation is likely not directly associated with quorum sensing. Instead, it can probably be attributed to non-specific interactions with the bacterial surface. This exploration provides valuable insights into the potential of quaternized chitosan nanoparticles in addressing
infections and underscores the multifaceted nature of their antimicrobial effects. |
|---|---|
| AbstractList | The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of
on the rise. Addressing this challenge necessitates exploring strategies that would complement existing antimicrobial agents,
by substances mitigating bacterial virulence without eliciting selective pressure for resistance emergence. In this respect, free-form chitosan has demonstrated promising efficacy, prompting our investigation into reinforcing its effects through nanoparticle formulations. Our study focuses on the preparation of chitosan nanoparticles under suitable conditions while emphasizing the challenges associated with stability that can affect biological activity. These challenges are mitigated by introducing quaternized chitosan, which ensures colloidal stability in the culture media. Our approach led to the production of trimethylchitosan nanoparticles with a median size of 103 nm, circularity of 0.967, and a charge of 14.9 ± 3.1 mV, stable within a one-month period in a water stock solution, showing promising attributes for further valorization. Furthermore, the study delves into the antimicrobial activity of trimethylchitosan nanoparticles on
and confirms the benefits of both nanoformulation and modification of chitosan, as our prepared nanoparticles inhibit 50% of the bacterial population at concentration ≥160 mg L
within tested strains. Additionally, we identified a concentration of 5 mg L
that no longer impedes bacterial growth, allowing reliable verification of the effect of the prepared nanoparticles on
virulence factors, including motility, protease activity, hemolytic activity, rhamnolipids, pyocyanin, and biofilm production. Although trimethylchitosan nanoparticles exhibit promise as an effective antibiofilm agent (reducing biofilm development by 50% at concentrations ranging from 80 to 160 mg L
) their impact on virulence manifestation is likely not directly associated with quorum sensing. Instead, it can probably be attributed to non-specific interactions with the bacterial surface. This exploration provides valuable insights into the potential of quaternized chitosan nanoparticles in addressing
infections and underscores the multifaceted nature of their antimicrobial effects. The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of Pseudomonas aeruginosa on the rise. Addressing this challenge necessitates exploring strategies that would complement existing antimicrobial agents, e.g. by substances mitigating bacterial virulence without eliciting selective pressure for resistance emergence. In this respect, free-form chitosan has demonstrated promising efficacy, prompting our investigation into reinforcing its effects through nanoparticle formulations. Our study focuses on the preparation of chitosan nanoparticles under suitable conditions while emphasizing the challenges associated with stability that can affect biological activity. These challenges are mitigated by introducing quaternized chitosan, which ensures colloidal stability in the culture media. Our approach led to the production of trimethylchitosan nanoparticles with a median size of 103 nm, circularity of 0.967, and a charge of 14.9 ± 3.1 mV, stable within a one-month period in a water stock solution, showing promising attributes for further valorization. Furthermore, the study delves into the antimicrobial activity of trimethylchitosan nanoparticles on Pseudomonas aeruginosa and confirms the benefits of both nanoformulation and modification of chitosan, as our prepared nanoparticles inhibit 50% of the bacterial population at concentration ≥160 mg L-1 within tested strains. Additionally, we identified a concentration of 5 mg L-1 that no longer impedes bacterial growth, allowing reliable verification of the effect of the prepared nanoparticles on Pseudomonas aeruginosa virulence factors, including motility, protease activity, hemolytic activity, rhamnolipids, pyocyanin, and biofilm production. Although trimethylchitosan nanoparticles exhibit promise as an effective antibiofilm agent (reducing biofilm development by 50% at concentrations ranging from 80 to 160 mg L-1) their impact on virulence manifestation is likely not directly associated with quorum sensing. Instead, it can probably be attributed to non-specific interactions with the bacterial surface. This exploration provides valuable insights into the potential of quaternized chitosan nanoparticles in addressing Pseudomonas aeruginosa infections and underscores the multifaceted nature of their antimicrobial effects.The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of Pseudomonas aeruginosa on the rise. Addressing this challenge necessitates exploring strategies that would complement existing antimicrobial agents, e.g. by substances mitigating bacterial virulence without eliciting selective pressure for resistance emergence. In this respect, free-form chitosan has demonstrated promising efficacy, prompting our investigation into reinforcing its effects through nanoparticle formulations. Our study focuses on the preparation of chitosan nanoparticles under suitable conditions while emphasizing the challenges associated with stability that can affect biological activity. These challenges are mitigated by introducing quaternized chitosan, which ensures colloidal stability in the culture media. Our approach led to the production of trimethylchitosan nanoparticles with a median size of 103 nm, circularity of 0.967, and a charge of 14.9 ± 3.1 mV, stable within a one-month period in a water stock solution, showing promising attributes for further valorization. Furthermore, the study delves into the antimicrobial activity of trimethylchitosan nanoparticles on Pseudomonas aeruginosa and confirms the benefits of both nanoformulation and modification of chitosan, as our prepared nanoparticles inhibit 50% of the bacterial population at concentration ≥160 mg L-1 within tested strains. Additionally, we identified a concentration of 5 mg L-1 that no longer impedes bacterial growth, allowing reliable verification of the effect of the prepared nanoparticles on Pseudomonas aeruginosa virulence factors, including motility, protease activity, hemolytic activity, rhamnolipids, pyocyanin, and biofilm production. Although trimethylchitosan nanoparticles exhibit promise as an effective antibiofilm agent (reducing biofilm development by 50% at concentrations ranging from 80 to 160 mg L-1) their impact on virulence manifestation is likely not directly associated with quorum sensing. Instead, it can probably be attributed to non-specific interactions with the bacterial surface. This exploration provides valuable insights into the potential of quaternized chitosan nanoparticles in addressing Pseudomonas aeruginosa infections and underscores the multifaceted nature of their antimicrobial effects. The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of Pseudomonas aeruginosa on the rise. Addressing this challenge necessitates exploring strategies that would complement existing antimicrobial agents, e.g. by substances mitigating bacterial virulence without eliciting selective pressure for resistance emergence. In this respect, free-form chitosan has demonstrated promising efficacy, prompting our investigation into reinforcing its effects through nanoparticle formulations. Our study focuses on the preparation of chitosan nanoparticles under suitable conditions while emphasizing the challenges associated with stability that can affect biological activity. These challenges are mitigated by introducing quaternized chitosan, which ensures colloidal stability in the culture media. Our approach led to the production of trimethylchitosan nanoparticles with a median size of 103 nm, circularity of 0.967, and a charge of 14.9 ± 3.1 mV, stable within a one-month period in a water stock solution, showing promising attributes for further valorization. Furthermore, the study delves into the antimicrobial activity of trimethylchitosan nanoparticles on Pseudomonas aeruginosa and confirms the benefits of both nanoformulation and modification of chitosan, as our prepared nanoparticles inhibit 50% of the bacterial population at concentration ≥160 mg L −1 within tested strains. Additionally, we identified a concentration of 5 mg L −1 that no longer impedes bacterial growth, allowing reliable verification of the effect of the prepared nanoparticles on Pseudomonas aeruginosa virulence factors, including motility, protease activity, hemolytic activity, rhamnolipids, pyocyanin, and biofilm production. Although trimethylchitosan nanoparticles exhibit promise as an effective antibiofilm agent (reducing biofilm development by 50% at concentrations ranging from 80 to 160 mg L −1 ) their impact on virulence manifestation is likely not directly associated with quorum sensing. Instead, it can probably be attributed to non-specific interactions with the bacterial surface. This exploration provides valuable insights into the potential of quaternized chitosan nanoparticles in addressing Pseudomonas aeruginosa infections and underscores the multifaceted nature of their antimicrobial effects. The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of Pseudomonas aeruginosa on the rise. The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of Pseudomonas aeruginosa on the rise. Addressing this challenge necessitates exploring strategies that would complement existing antimicrobial agents, e.g. by substances mitigating bacterial virulence without eliciting selective pressure for resistance emergence. In this respect, free-form chitosan has demonstrated promising efficacy, prompting our investigation into reinforcing its effects through nanoparticle formulations. Our study focuses on the preparation of chitosan nanoparticles under suitable conditions while emphasizing the challenges associated with stability that can affect biological activity. These challenges are mitigated by introducing quaternized chitosan, which ensures colloidal stability in the culture media. Our approach led to the production of trimethylchitosan nanoparticles with a median size of 103 nm, circularity of 0.967, and a charge of 14.9 ± 3.1 mV, stable within a one-month period in a water stock solution, showing promising attributes for further valorization. Furthermore, the study delves into the antimicrobial activity of trimethylchitosan nanoparticles on Pseudomonas aeruginosa and confirms the benefits of both nanoformulation and modification of chitosan, as our prepared nanoparticles inhibit 50% of the bacterial population at concentration ≥160 mg L −1 within tested strains. Additionally, we identified a concentration of 5 mg L −1 that no longer impedes bacterial growth, allowing reliable verification of the effect of the prepared nanoparticles on Pseudomonas aeruginosa virulence factors, including motility, protease activity, hemolytic activity, rhamnolipids, pyocyanin, and biofilm production. Although trimethylchitosan nanoparticles exhibit promise as an effective antibiofilm agent (reducing biofilm development by 50% at concentrations ranging from 80 to 160 mg L −1 ) their impact on virulence manifestation is likely not directly associated with quorum sensing. Instead, it can probably be attributed to non-specific interactions with the bacterial surface. This exploration provides valuable insights into the potential of quaternized chitosan nanoparticles in addressing Pseudomonas aeruginosa infections and underscores the multifaceted nature of their antimicrobial effects. |
| Author | Maršík, Dominik Masák, Jan Maťátková, Olga Kolková, Anna |
| Author_xml | – sequence: 1 givenname: Dominik orcidid: 0000-0002-7250-7762 surname: Maršík fullname: Maršík, Dominik email: marsikd@vscht.cz organization: Department of Biotechnology, University of Chemistry and Technology Technická 5, Prague 6 Prague 166 28 Czechia marsikd@vscht.cz – sequence: 2 givenname: Olga orcidid: 0000-0002-3646-9738 surname: Maťátková fullname: Maťátková, Olga email: marsikd@vscht.cz organization: Department of Biotechnology, University of Chemistry and Technology Technická 5, Prague 6 Prague 166 28 Czechia marsikd@vscht.cz – sequence: 3 givenname: Anna surname: Kolková fullname: Kolková, Anna email: marsikd@vscht.cz organization: Department of Biotechnology, University of Chemistry and Technology Technická 5, Prague 6 Prague 166 28 Czechia marsikd@vscht.cz – sequence: 4 givenname: Jan surname: Masák fullname: Masák, Jan email: marsikd@vscht.cz organization: Department of Biotechnology, University of Chemistry and Technology Technická 5, Prague 6 Prague 166 28 Czechia marsikd@vscht.cz |
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| Cites_doi | 10.1093/clinids/3.6.1127 10.3390/pr8091173 10.1038/srep23347 10.1128/JB.00117-19 10.1016/j.resmic.2018.02.001 10.1016/S0141-8130(97)01165-3 10.1016/j.jfoodeng.2005.01.047 10.1016/j.microc.2009.02.001 10.3390/toxins8080236 10.3390/ijms22073337 10.1128/CMR.00031-19 10.1016/j.carbpol.2017.12.011 10.1111/j.1365-3091.2007.00892.x 10.1016/j.ijbiomac.2020.02.019 10.1088/2057-1976/aac9f8 10.3389/fcimb.2022.993029 10.2147/DDDT.S99651 10.1016/j.jconrel.2015.10.006 10.1038/s41598-018-23064-4 10.3390/plants11030443 10.3389/fcimb.2013.00075 10.1007/s13238-014-0100-x 10.1016/j.ijbiomac.2020.05.109 10.1016/j.scp.2020.100300 10.1021/mp300162j 10.3934/microbiol.2021025 10.1038/nprot.2010.110 10.1093/femspd/ftz009 10.1038/s41598-023-41333-9 10.1016/j.drudis.2021.02.026 10.1046/j.1365-2958.1998.01062.x 10.1002/pat.1306 10.1016/j.ijmm.2010.08.005 10.1016/j.jconrel.2016.06.017 10.1016/j.biomaterials.2003.12.036 10.1016/j.carbpol.2017.02.001 10.1016/j.ijpharm.2007.07.035 10.3390/antibiotics9090551 10.1007/s00396-012-2604-3 10.3390/ijms20246297 10.1016/j.mimet.2023.106676 10.1016/j.polymer.2007.03.063 10.1016/j.colsurfb.2011.09.042 10.1016/j.bpj.2017.02.019 10.1016/j.ijbiomac.2017.08.146 10.3390/microorganisms10071272 10.1371/journal.pone.0058299 10.1038/nature24624 10.1007/s12649-023-02220-6 10.1016/j.jcis.2004.08.186 10.1016/j.jconrel.2005.01.001 10.3109/17435390.2012.724724 10.1016/j.ijbiomac.2018.08.130 10.7150/ijbs.5.153 10.3389/fimmu.2018.01675 10.1186/1471-2164-11-587 10.3389/fcimb.2021.656984 10.1080/14787210.2020.1750951 10.1128/JB.01623-06 10.1371/journal.pone.0272844 10.1016/j.colsurfb.2017.05.055 10.1016/j.ijbiomac.2024.129264 10.1021/acsbiomaterials.5b00502 10.1073/pnas.2101759118 10.1016/j.carbpol.2018.11.015 10.1007/s00289-023-04755-z 10.1002/(SICI)1097-4628(19970103)63:1<125::AID-APP13>3.0.CO;2-4 10.1016/j.jconrel.2008.08.020 10.1016/j.micpath.2019.01.033 10.1016/j.ijpharm.2008.06.029 10.1128/jb.152.1.239-245.1982 10.1371/journal.pone.0138209 10.1016/j.ijantimicag.2007.12.005 10.1016/j.biopha.2021.111970 10.1007/s13233-010-1004-0 10.1038/nature06279 10.1128/iai.55.7.1728-1730.1987 10.1016/j.bbamem.2007.04.024 10.1016/j.ijpharm.2020.119119 10.1128/JB.187.21.7351-7361.2005 10.1007/s10876-013-0583-2 10.1016/B978-0-12-397169-2.00041-X 10.3389/fcimb.2021.816356 10.1128/JB.01620-07 10.1007/s12272-011-0408-5 10.1099/mic.0.2008/018622-0 10.3390/pharmaceutics9040053 10.1016/j.chemosphere.2022.135950 10.3390/molecules26237136 10.1128/JB.182.21.5990-5996.2000 10.1016/S0169-409X(01)00231-9 10.1016/j.addr.2013.07.011 10.1038/s41598-018-30813-y 10.15171/apb.2019.023 10.3390/microorganisms9050912 10.1007/978-1-4939-0473-0_7 10.1016/0049-3848(88)90115-6 10.3389/fphar.2022.880377 10.1016/j.micpath.2017.11.011 10.1164/rccm.201103-0374OC |
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| References | Frigaard (D4NA00064A/cit1/1) 2022; 13 Coutinho (D4NA00064A/cit89/1) 1988; 51 Sayın (D4NA00064A/cit40/1) 2008; 363 Lee (D4NA00064A/cit46/1) 2015; 6 Karthick Raja Namasivayam (D4NA00064A/cit7/1) 2018; 120 Hickey (D4NA00064A/cit58/1) 2015; 219 Muslim (D4NA00064A/cit14/1) 2018; 107 Overhage (D4NA00064A/cit75/1) 2007; 189 Lo (D4NA00064A/cit97/1) 2018; 169 Piewngam (D4NA00064A/cit13/1) 2020; 18 Kiang (D4NA00064A/cit38/1) 2004; 25 Wang (D4NA00064A/cit84/1) 2018; 8 Cornelis (D4NA00064A/cit92/1) 2013; 3 Hall (D4NA00064A/cit91/1) 2016; 8 Ziuzina (D4NA00064A/cit106/1) 2015; 10 Rivera Aguayo (D4NA00064A/cit18/1) 2020; 9 Sreekumar (D4NA00064A/cit28/1) 2018; 8 Kean (D4NA00064A/cit57/1) 2005; 103 Piras (D4NA00064A/cit62/1) 2019; 20 Yang (D4NA00064A/cit74/1) 2017; 112 Mateu-Borrás (D4NA00064A/cit81/1) 2022; 11 Horcajada (D4NA00064A/cit12/1) 2019; 32 Yang (D4NA00064A/cit95/1) 2018; 84 Badawy (D4NA00064A/cit66/1) 2020; 149 Garg (D4NA00064A/cit4/1) 2019; 9 Mohammed (D4NA00064A/cit3/1) 2017; 9 Zhu (D4NA00064A/cit70/1) 2019; 201 Calvo (D4NA00064A/cit20/1) 1997; 63 Bullen (D4NA00064A/cit93/1) 1981; 3 Yang (D4NA00064A/cit29/1) 2009; 92 Berk (D4NA00064A/cit88/1) 1987; 55 Liu (D4NA00064A/cit24/1) 2009; 20 Ahmed (D4NA00064A/cit19/1) 2016; 10 Berka (D4NA00064A/cit86/1) 1982; 152 Rivera Aguayo (D4NA00064A/cit64/1) 2020; 9 Hu (D4NA00064A/cit48/1) 2007; 48 Thaya (D4NA00064A/cit67/1) 2018; 114 Songsurang (D4NA00064A/cit21/1) 2011; 34 Thanou (D4NA00064A/cit33/1) 2001; 52 Kašparová (D4NA00064A/cit104/1) 2022; 12 Das (D4NA00064A/cit96/1) 2013; 8 Miškovská (D4NA00064A/cit99/1) 2022; 17 Montes (D4NA00064A/cit87/1) 2007; 1768 Pelgrift (D4NA00064A/cit2/1) 2013; 65 Cho (D4NA00064A/cit34/1) 2006; 74 Melake (D4NA00064A/cit53/1) 2012; 6 Verlee (D4NA00064A/cit9/1) 2017; 164 Rubini (D4NA00064A/cit65/1) 2019; 77 Salis (D4NA00064A/cit54/1) 2016; 2 Whiteley (D4NA00064A/cit15/1) 2017; 551 Boks (D4NA00064A/cit94/1) 2008; 154 Maisetta (D4NA00064A/cit52/1) 2021; 9 Vaezifar (D4NA00064A/cit25/1) 2013; 24 Kulišová (D4NA00064A/cit101/1) 2023; 205 Geçer (D4NA00064A/cit39/1) 2010; 18 Bleves (D4NA00064A/cit79/1) 2010; 300 Karthick Raja Namasivayam (D4NA00064A/cit6/1) 2022; 308 Koukaras (D4NA00064A/cit26/1) 2012; 9 Diggle (D4NA00064A/cit83/1) 2007; 450 Tommonaro (D4NA00064A/cit16/1) 2019 Fattah (D4NA00064A/cit10/1) 2021; 7 Wu (D4NA00064A/cit71/1) 2015 Khan (D4NA00064A/cit63/1) 2019; 128 Caiazza (D4NA00064A/cit76/1) 2005; 187 Bhattacharjee (D4NA00064A/cit37/1) 2016; 235 Llanos (D4NA00064A/cit80/1) 2023; 13 Rathinam (D4NA00064A/cit51/1) 2020; 160 BLOTT (D4NA00064A/cit98/1) 2008; 55 Sánchez-Clemente (D4NA00064A/cit31/1) 2018; 2 Fan (D4NA00064A/cit30/1) 2012; 90 Lin (D4NA00064A/cit22/1) 2008; 132 Wargo (D4NA00064A/cit90/1) 2011; 184 Ozturk (D4NA00064A/cit32/1) 2020; 578 Murray (D4NA00064A/cit77/1) 2008; 190 Martins (D4NA00064A/cit55/1) 2018; 181 Chandrasekaran (D4NA00064A/cit60/1) 2020; 8 Dilnawaz (D4NA00064A/cit59/1) 2024; 81 Köhler (D4NA00064A/cit78/1) 2000; 182 Yan (D4NA00064A/cit61/1) 2021; 26 Tremblay (D4NA00064A/cit73/1) 2010; 11 Di Santo (D4NA00064A/cit23/1) 2021; 142 Raja Namasivayam (D4NA00064A/cit8/1) 2020; 17 Namasivayam (D4NA00064A/cit5/1) 2024; 259 Bastaert (D4NA00064A/cit82/1) 2018; 9 Everett (D4NA00064A/cit85/1) 2021; 26 Banik (D4NA00064A/cit41/1) 2016; 8 Rauscher (D4NA00064A/cit42/1) 2013; 7 Ikono (D4NA00064A/cit11/1) 2018; 4 López-León (D4NA00064A/cit44/1) 2005; 283 Maťátková (D4NA00064A/cit103/1) 2022; 10 Ha (D4NA00064A/cit68/1) 2014 Saeki (D4NA00064A/cit102/1) 2021; 11 Chen (D4NA00064A/cit56/1) 2008; 349 Sawtarie (D4NA00064A/cit36/1) 2017; 157 Jonassen (D4NA00064A/cit27/1) 2012; 290 Das (D4NA00064A/cit105/1) 2016; 6 Boudouaia (D4NA00064A/cit47/1) 2023; 15 Müsken (D4NA00064A/cit43/1) 2010; 5 Tré-Hardy (D4NA00064A/cit45/1) 2008; 31 Bouteiller (D4NA00064A/cit69/1) 2021; 22 Liu (D4NA00064A/cit50/1) 2019; 206 O'Toole (D4NA00064A/cit17/1) 1998; 30 Tsaih (D4NA00064A/cit35/1) 1997; 20 Tin (D4NA00064A/cit49/1) 2009; 5 Michailidu (D4NA00064A/cit100/1) 2022; 11 Kühn (D4NA00064A/cit72/1) 2021; 118 |
| References_xml | – volume: 3 start-page: 1127 year: 1981 ident: D4NA00064A/cit93/1 publication-title: Rev. Infect. Dis. doi: 10.1093/clinids/3.6.1127 contributor: fullname: Bullen – volume: 8 start-page: 1173 issue: 9 year: 2020 ident: D4NA00064A/cit60/1 publication-title: Processes doi: 10.3390/pr8091173 contributor: fullname: Chandrasekaran – volume: 6 start-page: 23347 year: 2016 ident: D4NA00064A/cit105/1 publication-title: Sci. Rep. doi: 10.1038/srep23347 contributor: fullname: Das – volume: 201 start-page: e00117 issue: 13 year: 2019 ident: D4NA00064A/cit70/1 publication-title: J. Bacteriol. doi: 10.1128/JB.00117-19 contributor: fullname: Zhu – volume: 169 start-page: 135 year: 2018 ident: D4NA00064A/cit97/1 publication-title: Res. Microbiol. doi: 10.1016/j.resmic.2018.02.001 contributor: fullname: Lo – volume: 20 start-page: 233 year: 1997 ident: D4NA00064A/cit35/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/S0141-8130(97)01165-3 contributor: fullname: Tsaih – volume: 74 start-page: 500 year: 2006 ident: D4NA00064A/cit34/1 publication-title: J. Food Eng. doi: 10.1016/j.jfoodeng.2005.01.047 contributor: fullname: Cho – volume: 92 start-page: 87 year: 2009 ident: D4NA00064A/cit29/1 publication-title: Microchem. J. doi: 10.1016/j.microc.2009.02.001 contributor: fullname: Yang – volume: 8 start-page: 271 year: 2016 ident: D4NA00064A/cit41/1 publication-title: Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol. contributor: fullname: Banik – volume: 8 start-page: 236 issue: 8 year: 2016 ident: D4NA00064A/cit91/1 publication-title: Toxins doi: 10.3390/toxins8080236 contributor: fullname: Hall – volume: 22 start-page: 3337 issue: 7 year: 2021 ident: D4NA00064A/cit69/1 publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22073337 contributor: fullname: Bouteiller – volume: 32 start-page: e00031 issue: 4 year: 2019 ident: D4NA00064A/cit12/1 publication-title: Clin. Microbiol. Rev. doi: 10.1128/CMR.00031-19 contributor: fullname: Horcajada – volume: 181 start-page: 1213 year: 2018 ident: D4NA00064A/cit55/1 publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2017.12.011 contributor: fullname: Martins – volume: 55 start-page: 31 year: 2008 ident: D4NA00064A/cit98/1 publication-title: Sedimentology doi: 10.1111/j.1365-3091.2007.00892.x contributor: fullname: BLOTT – volume: 149 start-page: 1109 year: 2020 ident: D4NA00064A/cit66/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2020.02.019 contributor: fullname: Badawy – volume: 4 start-page: 045026 year: 2018 ident: D4NA00064A/cit11/1 publication-title: Biomed. Phys. Eng. Express doi: 10.1088/2057-1976/aac9f8 contributor: fullname: Ikono – volume: 12 start-page: 993029 year: 2022 ident: D4NA00064A/cit104/1 publication-title: Front. Cell. Infect. Microbiol. doi: 10.3389/fcimb.2022.993029 contributor: fullname: Kašparová – volume: 10 start-page: 483 year: 2016 ident: D4NA00064A/cit19/1 publication-title: Drug Des., Dev. Ther. doi: 10.2147/DDDT.S99651 contributor: fullname: Ahmed – volume: 219 start-page: 536 year: 2015 ident: D4NA00064A/cit58/1 publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2015.10.006 contributor: fullname: Hickey – volume: 8 start-page: 4695 year: 2018 ident: D4NA00064A/cit28/1 publication-title: Sci. Rep. doi: 10.1038/s41598-018-23064-4 contributor: fullname: Sreekumar – volume: 11 start-page: 443 issue: 3 year: 2022 ident: D4NA00064A/cit100/1 publication-title: Plants doi: 10.3390/plants11030443 contributor: fullname: Michailidu – volume: 3 start-page: 75 year: 2013 ident: D4NA00064A/cit92/1 publication-title: Front. Cell. Infect. Microbiol. doi: 10.3389/fcimb.2013.00075 contributor: fullname: Cornelis – volume: 6 start-page: 26 year: 2015 ident: D4NA00064A/cit46/1 publication-title: Protein Cell doi: 10.1007/s13238-014-0100-x contributor: fullname: Lee – volume: 160 start-page: 548 year: 2020 ident: D4NA00064A/cit51/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2020.05.109 contributor: fullname: Rathinam – volume: 17 start-page: 100300 year: 2020 ident: D4NA00064A/cit8/1 publication-title: Sustainable Chem. Pharm. doi: 10.1016/j.scp.2020.100300 contributor: fullname: Raja Namasivayam – volume: 9 start-page: 2856 year: 2012 ident: D4NA00064A/cit26/1 publication-title: Mol. Pharm. doi: 10.1021/mp300162j contributor: fullname: Koukaras – volume: 7 start-page: 415 year: 2021 ident: D4NA00064A/cit10/1 publication-title: AIMS Microbiol. doi: 10.3934/microbiol.2021025 contributor: fullname: Fattah – volume: 5 start-page: 1460 year: 2010 ident: D4NA00064A/cit43/1 publication-title: Nat. Protoc. doi: 10.1038/nprot.2010.110 contributor: fullname: Müsken – volume: 77 start-page: ftz009 year: 2019 ident: D4NA00064A/cit65/1 publication-title: Pathog. Dis. doi: 10.1093/femspd/ftz009 contributor: fullname: Rubini – volume: 13 start-page: 14208 year: 2023 ident: D4NA00064A/cit80/1 publication-title: Sci. Rep. doi: 10.1038/s41598-023-41333-9 contributor: fullname: Llanos – volume: 26 start-page: 2108 year: 2021 ident: D4NA00064A/cit85/1 publication-title: Drug Discovery Today doi: 10.1016/j.drudis.2021.02.026 contributor: fullname: Everett – volume: 30 start-page: 295 year: 1998 ident: D4NA00064A/cit17/1 publication-title: Mol. Microbiol. doi: 10.1046/j.1365-2958.1998.01062.x contributor: fullname: O'Toole – volume: 20 start-page: 613 year: 2009 ident: D4NA00064A/cit24/1 publication-title: Polym. Adv. Technol. doi: 10.1002/pat.1306 contributor: fullname: Liu – volume: 300 start-page: 534 year: 2010 ident: D4NA00064A/cit79/1 publication-title: Int. J. Med. Microbiol. doi: 10.1016/j.ijmm.2010.08.005 contributor: fullname: Bleves – volume: 235 start-page: 337 year: 2016 ident: D4NA00064A/cit37/1 publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2016.06.017 contributor: fullname: Bhattacharjee – volume: 25 start-page: 5293 year: 2004 ident: D4NA00064A/cit38/1 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2003.12.036 contributor: fullname: Kiang – volume: 164 start-page: 268 year: 2017 ident: D4NA00064A/cit9/1 publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2017.02.001 contributor: fullname: Verlee – volume: 349 start-page: 226 year: 2008 ident: D4NA00064A/cit56/1 publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2007.07.035 contributor: fullname: Chen – volume: 9 start-page: 551 year: 2020 ident: D4NA00064A/cit64/1 publication-title: Antibiotics doi: 10.3390/antibiotics9090551 contributor: fullname: Rivera Aguayo – volume: 290 start-page: 919 year: 2012 ident: D4NA00064A/cit27/1 publication-title: Colloid Polym. Sci. doi: 10.1007/s00396-012-2604-3 contributor: fullname: Jonassen – volume: 20 start-page: 6297 year: 2019 ident: D4NA00064A/cit62/1 publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20246297 contributor: fullname: Piras – volume: 205 start-page: 106676 year: 2023 ident: D4NA00064A/cit101/1 publication-title: J. Microbiol. Methods doi: 10.1016/j.mimet.2023.106676 contributor: fullname: Kulišová – volume: 48 start-page: 3098 year: 2007 ident: D4NA00064A/cit48/1 publication-title: Polymer doi: 10.1016/j.polymer.2007.03.063 contributor: fullname: Hu – volume: 90 start-page: 21 year: 2012 ident: D4NA00064A/cit30/1 publication-title: Colloids Surf., B doi: 10.1016/j.colsurfb.2011.09.042 contributor: fullname: Fan – volume: 112 start-page: 1462 year: 2017 ident: D4NA00064A/cit74/1 publication-title: Biophys. J. doi: 10.1016/j.bpj.2017.02.019 contributor: fullname: Yang – volume: 107 start-page: 52 year: 2018 ident: D4NA00064A/cit14/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2017.08.146 contributor: fullname: Muslim – volume: 10 start-page: 1272 year: 2022 ident: D4NA00064A/cit103/1 publication-title: Microorganisms doi: 10.3390/microorganisms10071272 contributor: fullname: Maťátková – volume: 6 start-page: 5387 year: 2012 ident: D4NA00064A/cit53/1 publication-title: Afr. J. Microbiol. Res. contributor: fullname: Melake – volume: 8 start-page: e58299 year: 2013 ident: D4NA00064A/cit96/1 publication-title: PLoS One doi: 10.1371/journal.pone.0058299 contributor: fullname: Das – volume: 9 start-page: 551 issue: 9 year: 2020 ident: D4NA00064A/cit18/1 publication-title: Antibiotics doi: 10.3390/antibiotics9090551 contributor: fullname: Rivera Aguayo – volume: 551 start-page: 313 year: 2017 ident: D4NA00064A/cit15/1 publication-title: Nature doi: 10.1038/nature24624 contributor: fullname: Whiteley – volume: 15 start-page: 1267 year: 2023 ident: D4NA00064A/cit47/1 publication-title: Waste Biomass Valorization doi: 10.1007/s12649-023-02220-6 contributor: fullname: Boudouaia – volume: 283 start-page: 344 year: 2005 ident: D4NA00064A/cit44/1 publication-title: J. Colloid Interface Sci. doi: 10.1016/j.jcis.2004.08.186 contributor: fullname: López-León – volume: 103 start-page: 643 year: 2005 ident: D4NA00064A/cit57/1 publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2005.01.001 contributor: fullname: Kean – volume: 7 start-page: 1195 year: 2013 ident: D4NA00064A/cit42/1 publication-title: Nanotoxicology doi: 10.3109/17435390.2012.724724 contributor: fullname: Rauscher – volume: 120 start-page: 921 year: 2018 ident: D4NA00064A/cit7/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2018.08.130 contributor: fullname: Karthick Raja Namasivayam – volume: 5 start-page: 153 year: 2009 ident: D4NA00064A/cit49/1 publication-title: Int. J. Biol. Sci. doi: 10.7150/ijbs.5.153 contributor: fullname: Tin – volume: 9 start-page: 1675 year: 2018 ident: D4NA00064A/cit82/1 publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.01675 contributor: fullname: Bastaert – volume: 11 start-page: 587 year: 2010 ident: D4NA00064A/cit73/1 publication-title: BMC Genomics doi: 10.1186/1471-2164-11-587 contributor: fullname: Tremblay – volume: 11 start-page: 656984 year: 2021 ident: D4NA00064A/cit102/1 publication-title: Front. Cell. Infect. Microbiol. doi: 10.3389/fcimb.2021.656984 contributor: fullname: Saeki – volume: 18 start-page: 499 year: 2020 ident: D4NA00064A/cit13/1 publication-title: Expert Rev. Anti-Infect. Ther. doi: 10.1080/14787210.2020.1750951 contributor: fullname: Piewngam – volume: 189 start-page: 2164 year: 2007 ident: D4NA00064A/cit75/1 publication-title: J. Bacteriol. doi: 10.1128/JB.01623-06 contributor: fullname: Overhage – volume: 17 start-page: e0272844 year: 2022 ident: D4NA00064A/cit99/1 publication-title: PLoS One doi: 10.1371/journal.pone.0272844 contributor: fullname: Miškovská – volume: 157 start-page: 110 year: 2017 ident: D4NA00064A/cit36/1 publication-title: Colloids Surf., B doi: 10.1016/j.colsurfb.2017.05.055 contributor: fullname: Sawtarie – volume: 259 start-page: 129264 year: 2024 ident: D4NA00064A/cit5/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2024.129264 contributor: fullname: Namasivayam – volume: 2 start-page: 741 year: 2016 ident: D4NA00064A/cit54/1 publication-title: ACS Biomater. Sci. Eng. doi: 10.1021/acsbiomaterials.5b00502 contributor: fullname: Salis – volume: 118 start-page: e2101759118 year: 2021 ident: D4NA00064A/cit72/1 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.2101759118 contributor: fullname: Kühn – volume: 84 start-page: e00700 year: 2018 ident: D4NA00064A/cit95/1 publication-title: Appl. Environ. Microbiol. contributor: fullname: Yang – volume: 206 start-page: 412 year: 2019 ident: D4NA00064A/cit50/1 publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2018.11.015 contributor: fullname: Liu – volume: 81 start-page: 1071 year: 2024 ident: D4NA00064A/cit59/1 publication-title: Polym. Bull. doi: 10.1007/s00289-023-04755-z contributor: fullname: Dilnawaz – volume: 63 start-page: 125 year: 1997 ident: D4NA00064A/cit20/1 publication-title: J. Appl. Polym. Sci. doi: 10.1002/(SICI)1097-4628(19970103)63:1<125::AID-APP13>3.0.CO;2-4 contributor: fullname: Calvo – volume: 132 start-page: 141 year: 2008 ident: D4NA00064A/cit22/1 publication-title: J. Controlled Release doi: 10.1016/j.jconrel.2008.08.020 contributor: fullname: Lin – volume: 128 start-page: 363 year: 2019 ident: D4NA00064A/cit63/1 publication-title: Microb. Pathog. doi: 10.1016/j.micpath.2019.01.033 contributor: fullname: Khan – volume: 363 start-page: 139 year: 2008 ident: D4NA00064A/cit40/1 publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2008.06.029 contributor: fullname: Sayın – volume: 152 start-page: 239 year: 1982 ident: D4NA00064A/cit86/1 publication-title: J. Bacteriol. doi: 10.1128/jb.152.1.239-245.1982 contributor: fullname: Berka – volume: 10 start-page: e0138209 year: 2015 ident: D4NA00064A/cit106/1 publication-title: PLoS One doi: 10.1371/journal.pone.0138209 contributor: fullname: Ziuzina – volume: 31 start-page: 329 year: 2008 ident: D4NA00064A/cit45/1 publication-title: Int. J. Antimicrob. Agents doi: 10.1016/j.ijantimicag.2007.12.005 contributor: fullname: Tré-Hardy – volume: 142 start-page: 111970 year: 2021 ident: D4NA00064A/cit23/1 publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2021.111970 contributor: fullname: Di Santo – volume: 18 start-page: 986 year: 2010 ident: D4NA00064A/cit39/1 publication-title: Macromol. Res. doi: 10.1007/s13233-010-1004-0 contributor: fullname: Geçer – volume: 450 start-page: 411 year: 2007 ident: D4NA00064A/cit83/1 publication-title: Nature doi: 10.1038/nature06279 contributor: fullname: Diggle – volume: 55 start-page: 1728 year: 1987 ident: D4NA00064A/cit88/1 publication-title: Infect. Immun. doi: 10.1128/iai.55.7.1728-1730.1987 contributor: fullname: Berk – volume-title: Quorum Sensing: Molecular Mechanism and Biotechnological Application year: 2019 ident: D4NA00064A/cit16/1 contributor: fullname: Tommonaro – volume: 1768 start-page: 2365 year: 2007 ident: D4NA00064A/cit87/1 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamem.2007.04.024 contributor: fullname: Montes – volume: 578 start-page: 119119 year: 2020 ident: D4NA00064A/cit32/1 publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2020.119119 contributor: fullname: Ozturk – volume: 187 start-page: 7351 year: 2005 ident: D4NA00064A/cit76/1 publication-title: J. Bacteriol. doi: 10.1128/JB.187.21.7351-7361.2005 contributor: fullname: Caiazza – volume: 24 start-page: 891 year: 2013 ident: D4NA00064A/cit25/1 publication-title: J. Cluster Sci. doi: 10.1007/s10876-013-0583-2 contributor: fullname: Vaezifar – start-page: 753 volume-title: Molecular Medical Microbiology year: 2015 ident: D4NA00064A/cit71/1 doi: 10.1016/B978-0-12-397169-2.00041-X contributor: fullname: Wu – volume: 11 start-page: 816356 year: 2022 ident: D4NA00064A/cit81/1 publication-title: Front. Cell. Infect. Microbiol. doi: 10.3389/fcimb.2021.816356 contributor: fullname: Mateu-Borrás – volume: 190 start-page: 2700 year: 2008 ident: D4NA00064A/cit77/1 publication-title: J. Bacteriol. doi: 10.1128/JB.01620-07 contributor: fullname: Murray – volume: 34 start-page: 583 year: 2011 ident: D4NA00064A/cit21/1 publication-title: Arch. Pharmacal Res. doi: 10.1007/s12272-011-0408-5 contributor: fullname: Songsurang – volume: 154 start-page: 3122 year: 2008 ident: D4NA00064A/cit94/1 publication-title: Microbiology doi: 10.1099/mic.0.2008/018622-0 contributor: fullname: Boks – volume: 9 start-page: 53 issue: 4 year: 2017 ident: D4NA00064A/cit3/1 publication-title: Pharmaceutics doi: 10.3390/pharmaceutics9040053 contributor: fullname: Mohammed – volume: 308 start-page: 135950 year: 2022 ident: D4NA00064A/cit6/1 publication-title: Chemosphere doi: 10.1016/j.chemosphere.2022.135950 contributor: fullname: Karthick Raja Namasivayam – volume: 26 start-page: 7136 issue: 23 year: 2021 ident: D4NA00064A/cit61/1 publication-title: Molecules doi: 10.3390/molecules26237136 contributor: fullname: Yan – volume: 182 start-page: 5990 year: 2000 ident: D4NA00064A/cit78/1 publication-title: J. Bacteriol. doi: 10.1128/JB.182.21.5990-5996.2000 contributor: fullname: Köhler – volume: 52 start-page: 117 year: 2001 ident: D4NA00064A/cit33/1 publication-title: Adv. Drug Delivery Rev. doi: 10.1016/S0169-409X(01)00231-9 contributor: fullname: Thanou – volume: 65 start-page: 1803 year: 2013 ident: D4NA00064A/cit2/1 publication-title: Adv. Drug Delivery Rev. doi: 10.1016/j.addr.2013.07.011 contributor: fullname: Pelgrift – volume: 8 start-page: 13344 year: 2018 ident: D4NA00064A/cit84/1 publication-title: Sci. Rep. doi: 10.1038/s41598-018-30813-y contributor: fullname: Wang – volume: 9 start-page: 195 year: 2019 ident: D4NA00064A/cit4/1 publication-title: Adv. Pharm. Bull. doi: 10.15171/apb.2019.023 contributor: fullname: Garg – volume: 9 start-page: 912 issue: 5 year: 2021 ident: D4NA00064A/cit52/1 publication-title: Microorganisms doi: 10.3390/microorganisms9050912 contributor: fullname: Maisetta – start-page: 59 volume-title: Pseudomonas Methods and Protocols year: 2014 ident: D4NA00064A/cit68/1 doi: 10.1007/978-1-4939-0473-0_7 contributor: fullname: Ha – volume: 51 start-page: 495 year: 1988 ident: D4NA00064A/cit89/1 publication-title: Thromb. Res. doi: 10.1016/0049-3848(88)90115-6 contributor: fullname: Coutinho – volume: 13 start-page: 880377 year: 2022 ident: D4NA00064A/cit1/1 publication-title: Front. Pharmacol doi: 10.3389/fphar.2022.880377 contributor: fullname: Frigaard – volume: 114 start-page: 17 year: 2018 ident: D4NA00064A/cit67/1 publication-title: Microb. Pathog. doi: 10.1016/j.micpath.2017.11.011 contributor: fullname: Thaya – volume: 2 start-page: 1297 year: 2018 ident: D4NA00064A/cit31/1 publication-title: Proceedings contributor: fullname: Sánchez-Clemente – volume: 184 start-page: 345 year: 2011 ident: D4NA00064A/cit90/1 publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201103-0374OC contributor: fullname: Wargo |
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| Snippet | The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of
on the... The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of Pseudomonas... The escalating antibiotic resistance observed in bacteria poses a significant threat to society, with the global prevalence of resistant strains of Pseudomonas... |
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| Title | Exploring the antimicrobial potential of chitosan nanoparticles: synthesis, characterization and impact on Pseudomonas aeruginosa virulence factors |
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