Commercial-Scale Synthesis of Protected 2′-Deoxycytidine and Cytidine Nucleosides

Transformation of 2′-deoxyuridine and uridine analogs to protected 2′-deoxycytidine and cytidine analogs has been investigated by two different methods. First, traditional triazolation protocol and second p-nitrophenoxylation method. Our studies conclude that the triazolation method is better and su...

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Bibliographic Details
Published inNucleosides, nucleotides & nucleic acids Vol. 22; no. 5-8; pp. 1321 - 1325
Main Authors Divakar, Kikkeri J., Sawant, Chitra M., Mulla, Y. A., Zemse, Deepak V., Sitabkhan, Sakina M., Ross, Bruce S., Sanghvi, Yogesh S.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis Group 01.10.2003
Subjects
4-Nitrophenoxylation
Cytidine
Cytidine - analogs & derivatives
Cytidine - chemical synthesis
Deoxycytidine
Deoxycytidine - analogs & derivatives
Deoxycytidine - chemical synthesis
Indicators and Reagents
Molecular Conformation
Triazolation
Triazoles
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Summary:Transformation of 2′-deoxyuridine and uridine analogs to protected 2′-deoxycytidine and cytidine analogs has been investigated by two different methods. First, traditional triazolation protocol and second p-nitrophenoxylation method. Our studies conclude that the triazolation method is better and suitable for commercial scale--up.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-120022956