Safe and efficient treatment of drug-resistant colorectal cancer cells using kaempferol-loaded exosomes

• Published in: Biotechnology and bioprocess engineering Vol. 29; no. 6; pp. 1108 - 1117
• Main Authors: Min, Jun, Jeung, Dohyun, Lee, Dae Gyun, Kang, Hyeon Ju, Jo, Ha Young, Tram, Le Thi Hong, Kang, Han Chang, Lee, Joo Young, Lee, Hye Suk, Rhee, Won Jong, Kim, Byoung Choul, Cho, Yong-Yeon, Shim, Min Suk
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.12.2024; Springer Nature B.V; 한국생물공학회
• Subjects: antineoplastic activity; Antitumor activity; Bioavailability; Biotechnology; Cancer; Cell cycle; cell cycle checkpoints; Cell proliferation; Chemistry; Chemistry and Materials Science; Chemotherapy; Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; Cyclin-dependent kinase inhibitor p21; Drug resistance; drug therapy; drugs; Exosomes; Flavonols; GTP-binding protein; Industrial and Production Engineering; Kaempferol; Load resistance; nanocarriers; Oxaliplatin; Plant cells; Research Paper; Resistance factors; Side effects; 생물공학; Drug resistance; Exosome; Kaempferol; p21; Colorectal cancer

Drug resistance to chemotherapy is a primary factor contributing to recurrence in colorectal cancer patients. Therefore, the development of new chemotherapeutic strategies capable of overcoming drug resistance while minimizing side effects is crucial. Kaempferol (KF), a natural flavonol derived from...