Enhanced drug delivery in cancer therapy: role of TMPRSS4 protease in liposomal engineering

• Published in: Biotechnology and bioprocess engineering Vol. 30; no. 2; pp. 287 - 298
• Main Authors: Kim, Ji Hoon, Kwak, Jeong Hun, Choi, Ho Joong, Lee, Dosang, Park, Jung Hyun, Kim, Ok-Hee, Kim, Say-June
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Nature B.V 01.04.2025; 한국생물공학회
• Subjects: Apoptosis; Cancer therapies; cancer therapy; Cargo; Cell membranes; colon; Colon cancer; Destabilization; Doxorubicin; Drug delivery; Drug development; Efficiency; Gastric cancer; immunohistochemistry; In vivo methods and tests; Intracellular; Liposomes; lungs; Mcl-1 protein; Microfluidics; neoplasm cells; Pancreatic cancer; pancreatic neoplasms; Peptides; Protease; proteinases; Proteolysis; Research facilities; serine; Sonication; stomach neoplasms; Tumor cell lines; Tumor cells; Tumors; Xenografts; Xenotransplantation; 생물공학

This research centers on leveraging the proteolytic activity of TMPRSS4 (transmembrane protease, serine 4), a transmembrane protease frequently found on tumor cell membranes, for the development of anticancer therapeutics. A novel liposome design was developed, incorporating transmembrane peptides (...