Angiotensin II is a necessary component for the development of hypertension in the two kidney, one clip rat

• Published in: The American journal of cardiology Vol. 49; no. 6; pp. 1515 - 1517
• Main Authors: DeForrest, Jack M., Knappenberger, Richard C., Antonaccio, Michael J., Ferrone, Ronald A., Creekmore, Jay S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.04.1982
• Subjects: Angiotensin II - physiology; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure - drug effects; Captopril - pharmacology; Hypertension, Renal - physiopathology; Hypertension, Renovascular - physiopathology; Male; Rats; Rats, Inbred Strains; Renin - blood; Renin-Angiotensin System - drug effects

The current study was undertaken to define the role of the renin-angiotensin system in the development of hypertension in the two kidney, one clip Goldblatt rat. Captopril was administered orally (100 mg/kg/day) to two groups of rats (n = 8 each) 24 hours before and each day after unilateral renal a...