Asymmetric Synthesis of N–N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations

• Published in: Organic letters Vol. 24; no. 1; pp. 374 - 378
• Main Authors: Pan, Ming, Shao, Ying-Bo, Zhao, Qun, Li, Xin
• Format: Journal Article
• Language: English
• Published: WASHINGTON Amer Chemical Soc 14.01.2022
• Subjects: alkylation; catalytic activity; Chemistry; Chemistry, Organic; density functional theory; drugs; Physical Sciences; Science & Technology; stereoselective synthesis; ATROPOSELECTIVE SYNTHESIS

N-N axially chiral skeletons are significant structural motifs in natural products, pharmaceuticals, and functional materials. Herein we disclose a method for the asymmetric synthesis of N-N axially chiral compounds by phase-transfer catalysis. A wide range of N-N axially chiral quinazolinone deriva...