A Role for the Autophagic Receptor, SQSTM1/p62, in Trafficking NF-κB/RelA to Nucleolar Aggresomes

Elevated NF-κB activity is a contributory factor in many hematologic and solid malignancies. Nucleolar sequestration of NF-κB/RelA represses this elevated activity and mediates apoptosis of cancer cells. Here, we set out to understand the mechanisms that control the nuclear/nucleolar distribution of...

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Bibliographic Details
Published inMolecular cancer research Vol. 19; no. 2; pp. 274 - 287
Main Authors Lobb, Ian T, Morin, Pierre, Martin, Kirsty, Thoms, Hazel C, Wills, Jimi C, Lleshi, Xhordi, Olsen, Karl C F, Duncan, Rory R, Stark, Lesley A
Format Journal Article
LanguageEnglish
Published United States 01.02.2021
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