Phenacyl bromide: A versatile organic intermediate for the synthesis of heterocyclic compounds

Phenacyl bromides are used as a building blocks in synthetic organic chemistry, which serves as a key model for the development of various biologically important heterocyclic compounds and other industrially important scaffolds. This review covers recent synthetic advances in the preparation of hete...

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Bibliographic Details
Published inSynthetic communications Vol. 48; no. 13; pp. 1505 - 1533
Main Authors Vekariya, Rajesh H., Patel, Kinjal D., Prajapati, Neelam P., Patel, Hitesh D.
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 03.07.2018
Taylor & Francis Ltd
Subjects
Bromides
Chemical synthesis
Five-membered heterocyclic
fused heterocyclic compound
Heterocyclic compounds
multicomponent reactions
one-pot reaction
Organic chemistry
phenacyl bromides
six-membered heterocyclic
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Summary:Phenacyl bromides are used as a building blocks in synthetic organic chemistry, which serves as a key model for the development of various biologically important heterocyclic compounds and other industrially important scaffolds. This review covers recent synthetic advances in the preparation of heterocyclic compounds utilizing various phenacyl bromides. A wide range of five- and six-membered heterocyclic compounds as well as fused heterocyclic compounds were synthesized efficiently from the phenacyl bromide precursors through one-pot multicomponent reactions.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2017.1329440