Specificity of Quantitative Functional Brain Mapping with Arterial Spin-Labeling for Preoperative Assessment

• Published in: American journal of neuroradiology : AJNR Vol. 44; no. 11; pp. 1302 - 1308
• Main Authors: Iannotti, Giannina R., Nadin, Isaure, Ivanova, Vladimira, Tourdot, Quentin, Lascano, Agustina M., Momjian, Shahan, Schaller, Karl L., Lovblad, Karl O., Grouiller, Frederic
• Format: Journal Article
• Language: English
• Published: United States American Society of Neuroradiology 01.11.2023
• Subjects: Arteries; Brain - blood supply; Brain Mapping - methods; Cerebrovascular Circulation - physiology; Editor's Choice; Humans; Magnetic Resonance Imaging - methods; Neuroimaging Physics/Functional Neuroimaging/CT and MRI Technology; Spin Labels
• ISSN: 0195-6108; 1936-959X; 1936-959X
• DOI: 10.3174/ajnr.A8006

Arterial spin-labeling is a noninvasive MR imaging technique allowing direct and quantitative measurement of brain perfusion. Arterial spin-labeling is well-established in clinics for investigating the overall cerebral perfusion, but it is still occasionally employed during tasks. The typical contrast for functional MR imaging is blood oxygen level-dependent (BOLD) imaging, whose specificity could be biased in neurologic patients due to altered neurovascular coupling. This work aimed to validate the use of functional ASL as a noninvasive tool for presurgical functional brain mapping. This is achieved by comparing the spatial accuracy of functional ASL with transcranial magnetic stimulation as the criterion standard. Twenty-eight healthy participants executed a motor task and received a somatosensory stimulation, while BOLD imaging and arterial spin-labeling were acquired simultaneously. Transcranial magnetic stimulation was subsequently used to define hand somatotopy. Functional ASL was found more adjacent to transcranial magnetic stimulation than BOLD imaging, with a significant shift along the inferior-to-superior direction. With respect to BOLD imaging, functional ASL was localized significantly more laterally, anteriorly, and inferiorly during motor tasks and pneumatic stimulation. Our results confirm the specificity of functional ASL in targeting the regional neuronal excitability. Functional ASL could be considered as a valid supplementary technique to BOLD imaging for presurgical mapping when spatial accuracy is crucial for delineating eloquent cortex.