LncRNA THEMIS2-211, a tumor-originated circulating exosomal biomarker, promotes the growth and metastasis of hepatocellular carcinoma by functioning as a competing endogenous RNA

• Published in: The FASEB journal Vol. 36; no. 4; p. e22238
• Main Authors: Yao, Jiyou, Hua, Xuefeng, Shi, Jiewei, Hu, Xiaoyuan, Lui, Kayin, He, Kaitao, Mai, Jialuo, Lan, Tian, Lu, Minqiang
• Format: Journal Article
• Language: English
• Published: United States 01.04.2022
• Subjects: Animals; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - secondary; Cell Proliferation; Disease Progression; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins - genetics; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Mice; Mice, Nude; Proteoglycans - genetics; Proteoglycans - metabolism; RNA, Long Noncoding - genetics; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; HCC; SPOCK1; miR-940; lncRNA; exosomes

Hepatocellular carcinoma (HCC) is a major challenge for human health. Finding reliable diagnostic biomarkers and therapeutic targets for HCC is highly desired in the clinic. Currently, circulating exosomal lncRNA is a promising biomarker for the diagnosis of cancer and lncRNA is also a potential tar...