Disturbances of the gut microbiota-derived tryptophan metabolites as key actors in vagotomy-induced mastitis in mice

• Published in: Cell reports (Cambridge) Vol. 43; no. 8; p. 114585
• Main Authors: He, Yuhong, Zhao, Caijun, Su, Niri, Yang, Wencheng, Yang, Hengyi, Yuan, Chongshan, Zhang, Naisheng, Hu, Xiaoyu, Fu, Yunhe
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.08.2024; Elsevier
• Subjects: 5-HIAA; Animals; CP: Metabolism; CP: Microbiology; Dysbiosis - metabolism; Dysbiosis - microbiology; Fecal Microbiota Transplantation; Female; Gastrointestinal Microbiome; gut microbiota; Mammary Glands, Animal - metabolism; Mammary Glands, Animal - microbiology; Mammary Glands, Animal - pathology; mastitis; Mastitis - metabolism; Mastitis - microbiology; Mice; Mice, Inbred C57BL; NF-kappa B - metabolism; Receptors, Aryl Hydrocarbon - metabolism; Tryptophan - metabolism; Vagotomy; Vagus Nerve - metabolism; mastitis; tryptophan metabolism; 5-HIAA; CP: Metabolism; vagotomy; CP: Microbiology; gut microbiota

Previous studies have demonstrated that gut microbiota dysbiosis promotes the development of mastitis. The interaction of the vagus nerve and gut microbiota endows host homeostasis and regulates disease development, but whether the vagus nerve participates in the pathogenesis of mastitis is unclear....