Can we enhance osteoporotic metaphyseal fracture healing through enhancing ultrastructural and functional changes of osteocytes in cortical bone with low-magnitude high-frequency vibration?

• Published in: The FASEB journal Vol. 34; no. 3; p. 4234
• Main Authors: Choy, Man-Huen Victoria, Wong, Ronald Man-Yeung, Li, Meng-Chen, Wang, Bai Yan, Liu, Xiao Dong, Lee, Wayne, Cheng, Jack Chun-Yiu, Chow, Simon Kwoon-Ho, Cheung, Wing-Hoi
• Format: Journal Article
• Language: English
• Published: United States 01.03.2020
• Subjects: Animals; Bone Density - physiology; Female; Fracture Healing - physiology; Immunohistochemistry; Mechanical Tests; Microscopy, Confocal; Microscopy, Electron, Scanning; Osteocytes - cytology; Osteoporotic Fractures - metabolism; Osteoporotic Fractures - therapy; Ovariectomy; Rats; Rats, Sprague-Dawley; Vibration - therapeutic use; X-Ray Microtomography; mechanical loading; osteoporotic fracture healing; lacuna-canalicular network (LCN); osteocytes; vibration

Fragility fractures are related to the loss of bone integrity and deteriorated morphology of osteocytes. Our previous studies have reported that low-magnitude high-frequency vibration (LMHFV) promoted osteoporotic fracture healing. As osteocytes are known for mechanosensing and initiating bone repai...