Targeted inhibition of allergen-induced histamine production by neutrophils

• Published in: The FASEB journal Vol. 35; no. 5; p. e21483
• Main Authors: Chacón, Pedro, Vega-Rioja, Antonio, Doukkali, Bouchra, Del Valle Rodríguez, Alberto, Bellido, Virginia, Puente, Yolanda, Alcañiz, Lorena, Rodríguez, David, Palacios, Ricardo, Cornejo-García, José Antonio, Monteseirín, Javier, Rivas-Pérez, David
• Format: Journal Article
• Language: English
• Published: United States 01.05.2021
• Subjects: diamine oxidase; asthma; histamine; histidine decarboxylase; allergen immunotherapy

Histamine is a critical inflammatory mediator in allergic diseases. We showed in a previous work that neutrophils from allergic patients produce histamine in response to allergens to which the patients were sensitized. Here, we investigate the molecular mechanisms involved in this process using peri...