Determination of urinary 13C-caffeine metabolites by liquid chromatography–mass spectrometry: the use of metabolic ratios to assess CYP1A2 activity

A method using liquid chromatography coupled with mass spectrometry with an atmospheric pressure electrospray source was developed for analysis of labelled caffeine and fourteen of its metabolites in urine. Caffeine metabolic ratios were determined after an oral bolus of labelled caffeine in 20 heal...

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Published inJournal of pharmaceutical and biomedical analysis Vol. 34; no. 2; pp. 379 - 389
Main Authors Caubet, Marie-Sophie, Comte, Blandine, Brazier, Jean-Louis
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.02.2004
Elsevier Science
Elsevier
Subjects
Adolescent
Adult
Analysis
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Caffeine - urine
Caffeine metabolic ratios
Carbon Isotopes - urine
Chromatography, High Pressure Liquid - methods
CYP1A2
Cytochrome P-450 CYP1A2 - urine
Enzyme Activation - physiology
Female
Fundamental and applied biological sciences. Psychology
General pharmacology
Humans
Isoenzymes - urine
Labelled caffeine
LC–MS
Life Sciences
Male
Medical sciences
Pharmaceutical sciences
Pharmacology
Pharmacology. Drug treatments
Statistics, Nonparametric
Caffeine metabolic ratios
Labelled caffeine
LC–MS
CYP1A2
CNS stimulant
Metabolite
Psychotropic
Cytochrome P450
Liquid chromatography
CYPI A2
Metabolism
Respiratory analeptic
Spectrometry
LC-MS
Xanthine derivatives
Quantitative analysis
Caffeine
labelled caffeine
caffeine metabolic ratios
Online AccessGet full text
ISSN0731-7085
1873-264X
DOI10.1016/S0731-7085(03)00528-4

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Abstract A method using liquid chromatography coupled with mass spectrometry with an atmospheric pressure electrospray source was developed for analysis of labelled caffeine and fourteen of its metabolites in urine. Caffeine metabolic ratios were determined after an oral bolus of labelled caffeine in 20 healthy subjects with different characteristic CYP1A2 activity, relative to smoking habit and oral contraceptive intake. The use of labelled caffeine for the calculation of metabolic ratios avoided taking into account the important background of endogenous caffeine metabolites, very difficult to eliminate even after a specific diet. The selectivity and high sensitivity of mass spectrometry detection allowed urine collections for only a 3 h period. Comparison between characteristic groups showed that labelled caffeine metabolic ratios were sensitive markers of changes in CYP1A2 activity.
AbstractList A method using liquid chromatography coupled with mass spectrometry with an atmospheric pressure electrospray source was developed for analysis of labelled caffeine and fourteen of its metabolites in urine. Caffeine metabolic ratios were determined after an oral bolus of labelled caffeine in 20 healthy subjects with different characteristic CYP1A2 activity, relative to smoking habit and oral contraceptive intake. The use of labelled caffeine for the calculation of metabolic ratios avoided taking into account the important background of endogenous caffeine metabolites, very difficult to eliminate even after a specific diet. The selectivity and high sensitivity of mass spectrometry detection allowed urine collections for only a 3h period. Comparison between characteristic groups showed that labelled caffeine metabolic ratios were sensitive markers of changes in CYP1A2 activity.
A method using liquid chromatography coupled with mass spectrometry with an atmospheric pressure electrospray source was developed for analysis of labelled caffeine and fourteen of its metabolites in urine. Caffeine metabolic ratios were determined after an oral bolus of labelled caffeine in 20 healthy subjects with different characteristic CYP1A2 activity, relative to smoking habit and oral contraceptive intake. The use of labelled caffeine for the calculation of metabolic ratios avoided taking into account the important background of endogenous caffeine metabolites, very difficult to eliminate even after a specific diet. The selectivity and high sensitivity of mass spectrometry detection allowed urine collections for only a 3h period. Comparison between characteristic groups showed that labelled caffeine metabolic ratios were sensitive markers of changes in CYP1A2 activity.A method using liquid chromatography coupled with mass spectrometry with an atmospheric pressure electrospray source was developed for analysis of labelled caffeine and fourteen of its metabolites in urine. Caffeine metabolic ratios were determined after an oral bolus of labelled caffeine in 20 healthy subjects with different characteristic CYP1A2 activity, relative to smoking habit and oral contraceptive intake. The use of labelled caffeine for the calculation of metabolic ratios avoided taking into account the important background of endogenous caffeine metabolites, very difficult to eliminate even after a specific diet. The selectivity and high sensitivity of mass spectrometry detection allowed urine collections for only a 3h period. Comparison between characteristic groups showed that labelled caffeine metabolic ratios were sensitive markers of changes in CYP1A2 activity.
A method using liquid chromatography coupled with mass spectrometry with an atmospheric pressure electrospray source was developed for analysis of labelled caffeine and fourteen of its metabolites in urine. Caffeine metabolic ratios were determined after an oral bolus of labelled caffeine in 20 healthy subjects with different characteristic CYP1A2 activity, relative to smoking habit and oral contraceptive intake. The use of labelled caffeine for the calculation of metabolic ratios avoided taking into account the important background of endogenous caffeine metabolites, very difficult to eliminate even after a specific diet. The selectivity and high sensitivity of mass spectrometry detection allowed urine collections for only a 3 h period. Comparison between characteristic groups showed that labelled caffeine metabolic ratios were sensitive markers of changes in CYP1A2 activity..
A method using liquid chromatography coupled with mass spectrometry with an atmospheric pressure electrospray source was developed for analysis of labelled caffeine and fourteen of its metabolites in urine. Caffeine metabolic ratios were determined after an oral bolus of labelled caffeine in 20 healthy subjects with different characteristic CYP1A2 activity, relative to smoking habit and oral contraceptive intake. The use of labelled caffeine for the calculation of metabolic ratios avoided taking into account the important background of endogenous caffeine metabolites, very difficult to eliminate even after a specific diet. The selectivity and high sensitivity of mass spectrometry detection allowed urine collections for only a 3 h period. Comparison between characteristic groups showed that labelled caffeine metabolic ratios were sensitive markers of changes in CYP1A2 activity.
Author Comte, Blandine
Caubet, Marie-Sophie
Brazier, Jean-Louis
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  givenname: Jean-Louis
  surname: Brazier
  fullname: Brazier, Jean-Louis
  organization: Faculté de Pharmacie, University of Montreal, Montreal, Que., Canada H3C 3J7
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Issue 2
Keywords Caffeine metabolic ratios
Labelled caffeine
LC–MS
CYP1A2
CNS stimulant
Metabolite
Psychotropic
Cytochrome P450
Liquid chromatography
CYPI A2
Metabolism
Respiratory analeptic
Spectrometry
LC-MS
Xanthine derivatives
Quantitative analysis
Caffeine
labelled caffeine
caffeine metabolic ratios
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Snippet A method using liquid chromatography coupled with mass spectrometry with an atmospheric pressure electrospray source was developed for analysis of labelled...
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SubjectTerms Adolescent
Adult
Analysis
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Caffeine - urine
Caffeine metabolic ratios
Carbon Isotopes - urine
Chromatography, High Pressure Liquid - methods
CYP1A2
Cytochrome P-450 CYP1A2 - urine
Enzyme Activation - physiology
Female
Fundamental and applied biological sciences. Psychology
General pharmacology
Humans
Isoenzymes - urine
Labelled caffeine
LC–MS
Life Sciences
Male
Medical sciences
Pharmaceutical sciences
Pharmacology
Pharmacology. Drug treatments
Statistics, Nonparametric
Title Determination of urinary 13C-caffeine metabolites by liquid chromatography–mass spectrometry: the use of metabolic ratios to assess CYP1A2 activity
URI https://dx.doi.org/10.1016/S0731-7085(03)00528-4
https://www.ncbi.nlm.nih.gov/pubmed/15013152
https://www.proquest.com/docview/71721658
https://hal.inrae.fr/hal-03324994
Volume 34
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