A single amino acid in the F2 subunit of respiratory syncytial virus fusion protein alters growth and fusogenicity

• Published in: Journal of general virology Vol. 94; no. 12; pp. 2627 - 2635
• Main Authors: Lawlor, Heather A., Schickli, Jeanne H., Tang, Roderick S.
• Format: Journal Article
• Language: English
• Published: England Society for General Microbiology 01.12.2013
• Subjects: Animal; Animals; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Giant Cells - physiology; Humans; Models, Molecular; Mutation; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - virology; Respiratory Syncytial Virus, Human - genetics; Respiratory Syncytial Virus, Human - growth & development; Respiratory Syncytial Virus, Human - pathogenicity; Vero Cells; Viral Fusion Proteins - chemistry; Viral Fusion Proteins - genetics; Viral Fusion Proteins - metabolism

Respiratory syncytial virus (RSV) causes severe lower respiratory tract infection in children, especially in infants less than 1 year of age. There are currently no licensed vaccines against RSV. rA2ΔM2-2 is a promising live-attenuated vaccine candidate that is currently being evaluated in the clini...