The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity

• Published in: Nature communications Vol. 15; no. 1; pp. 8411 - 12
• Main Authors: Garcia-Vello, Pilar, Tytgat, Hanne L. P., Elzinga, Janneke, Van Hul, Matthias, Plovier, Hubert, Tiemblo-Martin, Marta, Cani, Patrice D., Nicolardi, Simone, Fragai, Marco, De Castro, Cristina, Di Lorenzo, Flaviana, Silipo, Alba, Molinaro, Antonio, de Vos, Willem M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.09.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 140/131; 631/250/347; 631/326/41/2533; 631/45/72/1205; 64/60; 82/58; 96/106; 96/95; Akkermansia; Akkermansia muciniphila; Animals; Bacteria; Chain branching; Digestive system; Female; Gastrointestinal Microbiome; Gastrointestinal tract; Gene expression; Glycan; Gram-negative bacteria; Humanities and Social Sciences; Humans; Immune system; Inflammation; Inflammatory response; Innate immunity; Interleukin-10 - metabolism; Lipid A; Lipid A - chemistry; Lipid A - metabolism; Lipids; Lipooligosaccharides; Lipopolysaccharides; Liver - metabolism; Liver - microbiology; Mice; Mice, Inbred C57BL; Mucosal immunity; multidisciplinary; Polysaccharides; Proteins; Receptor mechanisms; Science; Science (multidisciplinary); Signal Transduction; Symbiosis; TLR2 protein; TLR4 protein; Toll-Like Receptor 2 - metabolism; Toll-Like Receptor 4 - metabolism; Toll-like receptors

The cell-envelope of Gram-negative bacteria contains endotoxic lipopolysaccharides (LPS) that are recognized by the innate immune system via Toll-Like Receptors (TLRs). The intestinal mucosal symbiont Akkermansia muciniphila is known to confer beneficial effects on the host and has a Gram-negative a...