Cerebrospinal Pharmacokinetic Analysis and Pharmacodynamic Evaluation of Ceftriaxone in Pediatric Patients with Bacterial Meningitis

• Published in: Journal of clinical pharmacy and therapeutics Vol. 2024; no. 1
• Main Authors: Onita, Tetsushu, Ikawa, Kazuro, Ishihara, Noriyuki, Tamaki, Hiroki, Yano, Takahisa, Morikawa, Norifumi, Naora, Kohji
• Format: Journal Article
• Language: English
• Published: Oxford Hindawi 2024; John Wiley & Sons, Inc
• Subjects: Antibiotics; Antimicrobial agents; Bacteria; Body weight; Ceftriaxone; Cerebrospinal fluid; Data integrity; Dosage; Drug dosages; Estimates; Meningitis; Minimum inhibitory concentration; Mortality; Pathogens; Patients; Pediatrics; Pharmacodynamics; Pharmacokinetics; Population; Random variables; Statistical analysis; Streptococcus infections
• ISSN: 0269-4727; 1365-2710
• DOI: 10.1155/2024/4684986

What Is Known? and Objective. Ceftriaxone has been widely used to treat bacterial meningitis in pediatric patients. Ceftriaxone dosing regimens of 80–120 mg/kg/day have been recommended for bacterial meningitis in pediatric patients, and the usual duration of therapy is 7–14 days. Although the targe...