Extending PTR based breath analysis to real-time monitoring of reactive volatile organic compounds

• Published in: Analyst (London) Vol. 144; no. 24; pp. 7359 - 7367
• Main Authors: Pugliese, Giovanni, Trefz, Phillip, Brock, Beate, Schubert, Jochen K, Miekisch, Wolfram
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 02.12.2019
• Subjects: Acetone; Adult; Aliphatic amines; Breath Tests - methods; Calibration; Design optimization; Diet, High-Protein; Diet, Protein-Restricted; Drift tubes; Electric fields; Female; Humans; In vivo methods and tests; Limit of Detection; Linearity; Male; Mass spectrometry; Mass Spectrometry - methods; Mathematical analysis; Middle Aged; Monitoring; Nitrogen; Proof of Concept Study; Protein metabolism; Proteins; Reaction time; Trimethylamine; VOCs; Volatile organic compounds; Volatile Organic Compounds - analysis; Young Adult

Reactive exhaled volatile organic compounds (VOCs) such as nitrogen- and sulfur-containing substances may be related to diseases, metabolic processes and bacterial activity. As these compounds may interact with any surface of the analytical system, time-resolved monitoring and reliable quantificatio...