Two-hour infusion of vasoactive intestinal polypeptide induces delayed headache and extracranial vasodilation in healthy volunteers

• Published in: Cephalalgia Vol. 40; no. 11; pp. 1212 - 1223
• Main Authors: Pellesi, Lanfranco, Al-Karagholi, Mohammad Al-Mahdi, Chaudhry, Basit Ali, Lopez, Cristina Lopez, Snellman, Josefin, Hannibal, Jens, Amin, Faisal Mohammad, Ashina, Messoud
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.10.2020
• Subjects: parasympathetic system; PACAP27; PACAP38; VIP; Migraine

Background In recent years, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptides (PACAPs) have gained special interest in headache science. VIP and PACAPs (two isoforms, PACAP27 and PACAP38) are related in structure and function, as are their receptors, but the...