Exosomes Derived from Human Placental Mesenchymal Stromal Cells Carrying AntagomiR-4450 Alleviate Intervertebral Disc Degeneration Through Upregulation of ZNF121

• Published in: Stem cells and development Vol. 29; no. 16; p. 1038
• Main Authors: Yuan, Qiling, Wang, Xinyi, Liu, Liang, Cai, Yongsong, Zhao, Xiaoming, Ma, Hongyun, Zhang, Yingang
• Format: Journal Article
• Language: English
• Published: United States 01.08.2020
• Subjects: intervertebral disc degeneration; ZNF121; microRNA-4450; human placental mesenchymal stromal cell; exosome; nucleus pulposus

Exosomes derived from mesenchymal stromal cells (MSCs) have emerged as novel drug and gene delivery tools. Current study aimed to elucidate the potential therapeutic role of human placental MSC (hPLMSC)-derived exosomes carrying AntagomiR-4450 (EXO-AntagomiR-4450) in intervertebral disc degeneration...