Growth Hormone Deficiency in Patients with Sickle Cell Disease and Growth Failure

• Published in: Journal of Pediatric Endocrinology and Metabolism Vol. 17; no. 4; pp. 601 - 606
• Main Authors: Nunlee-Bland, G., Rana, S.R., Houston-Yu, P.E., Odonkor, W.
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.04.2004
• Subjects: Adolescent; Adult; Anemia, Sickle Cell - complications; Body Height - drug effects; Child; Female; Growth - drug effects; Growth Disorders - etiology; Growth Disorders - pathology; Growth Disorders - physiopathology; Human Growth Hormone - analogs & derivatives; Human Growth Hormone - deficiency; Human Growth Hormone - therapeutic use; Humans; Male; Retrospective Studies; Steroid Metabolism, Inborn Errors - complications; Steroid Metabolism, Inborn Errors - drug therapy

Growth disorders are common in children with sickle cell disease (SCD). The etiology for growth disturbances in this population appears to be multifactorial. Recent evidence suggests abnormalities in the growth hormone (GH)/insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) axi...