Variety Is the Spice of Life: Positive and Negative Effects of Noise in Electrical Stimulation of the Nervous System

• Published in: The Neuroscientist (Baltimore, Md.) Vol. 27; no. 5; p. 529
• Main Authors: Howard, Calvin W, Toossi, Amirali, Mushahwar, Vivian K
• Format: Journal Article
• Language: English
• Published: United States 01.10.2021
• Subjects: Electric Stimulation; Humans; Neurons; Spinal Cord Injuries; noise; stochastic; intraspinal microstimulation; spinal cord; neurostimulation

Noisy stimuli may hold the key for optimal electrical stimulation of the nervous system. Possible mechanisms of noise's impact upon neuronal function are discussed, including intracellular, extracellular, and systems-level mechanisms. Specifically, channel resonance, stochastic resonance, high...