Shadow enhancers modulate distinct transcriptional parameters that differentially effect downstream patterning events

• Published in: Development (Cambridge) Vol. 149; no. 21
• Main Authors: Whitney, Peter H, Shrestha, Bikhyat, Xiong, Jiahan, Zhang, Tom, Rushlow, Christine A
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.11.2022
• Subjects: Animals; Drosophila - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Enhancer Elements, Genetic - genetics; Gastrulation; Gene Expression Regulation, Developmental; MS2 live imaging; Morphogen gradient; Shadow enhancers; Drosophila; Transcriptional kinetics

Transcription in the early Drosophila blastoderm is coordinated by the collective action of hundreds of enhancers. Many genes are controlled by so-called 'shadow enhancers', which provide resilience to environment or genetic insult, allowing the embryo to robustly generate a precise transc...