A dandelion-like liposomes-encoded magnetic bead probe-based toehold-mediated DNA circuit for the amplification detection of MiRNA

• Published in: Analyst (London) Vol. 144; no. 15; pp. 4694 - 471
• Main Authors: Kong, Yancong, Liu, Xiaowen, Liu, Chunxue, Xue, Qingwang, Li, Xia, Wang, Huaisheng
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 07.08.2019
• Subjects: Amplification; Amylose - chemistry; Cell Line, Tumor; Chemistry Techniques, Analytical - methods; Circuits; Deoxyribonucleic acid; Diagnosis; Dismantling; Displacement; DNA; DNA - chemistry; DNA - genetics; DNA Probes - chemistry; DNA Probes - genetics; Encapsulation; Gels; Glucan 1,4-alpha-Glucosidase - chemistry; Glucoamylase; Glucose; Glucose - analysis; Glucose - chemical synthesis; Humans; Limit of Detection; Liposomes; Liposomes - chemistry; Magnetic Phenomena; Magnetic separation; MicroRNAs - analysis; MicroRNAs - genetics; Nucleic Acid Amplification Techniques - methods; Nucleic Acid Hybridization; Recycling; Strategy

The development of facile and sensitive miRNA quantitative detection methods is a central challenge for the early diagnosis of miRNA-related diseases. Herein, we propose a strategy for a liposome-encoded magnetic bead-based DNA toehold-mediated DNA circuit for the simple and sensitive detection of m...