A solid-state NMR method for characterization of pharmaceutical eutectics

Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1 H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experim...

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Published inPhysical chemistry chemical physics : PCCP Vol. 26; no. 5; pp. 38 - 383
Main Authors Hareendran, Chaithanya, Shaligram, Parth S, Gonnade, Rajesh, Ajithkumar, T. G
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 31.01.2024
Subjects
Eutectics
Hydrogen bonding
NMR
Nuclear magnetic resonance
Pharmaceuticals
Solid state
Online AccessGet full text
ISSN1463-9076
1463-9084
1463-9084
DOI10.1039/d3cp05615e

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Abstract Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1 H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions. 2D 1 H- 1 H double quantum single quantum (DQSQ) correlation SSNMR experiment is demonstrated which can confirm the formation of pharmaceutical eutectics for which there are no techniques other than differential scanning calorimetry (DSC).
AbstractList Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions.Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions.
Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1 H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions. 2D 1 H- 1 H double quantum single quantum (DQSQ) correlation SSNMR experiment is demonstrated which can confirm the formation of pharmaceutical eutectics for which there are no techniques other than differential scanning calorimetry (DSC).
Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions.
Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions.
Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1 H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions.
Author Hareendran, Chaithanya
Gonnade, Rajesh
Ajithkumar, T. G
Shaligram, Parth S
AuthorAffiliation Central NMR facility and Physical/Materials Chemistry Division
CSIR-National Chemical Laboratory
Physical/Materials Chemistry Division
Academy of Scientific and Innovative Research (AcSIR)
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CitedBy_id crossref_primary_10_2174_0115734110315088240516072328
crossref_primary_10_1016_j_molstruc_2024_140451
crossref_primary_10_1021_acs_jpclett_3c03532
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SubjectTerms Eutectics
Hydrogen bonding
NMR
Nuclear magnetic resonance
Pharmaceuticals
Solid state
Title A solid-state NMR method for characterization of pharmaceutical eutectics
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